Research team

Global Health Institute (GHI)

Expertise

anythig concerning pelvic floor pathology ,myoma, endometriosis, preeclampsia, pregnancy, prenatal ultrasound, maternal health care perinatal mental healh care pelvic organ proalps pop gynaecologic and pelvic surgery laparoscopy pelvic floor ultrasound preterm birth pprom infections in pregnancy

Sustaining, deepening and expanding the Sub-Saharian HPV research network (WAKA-HPV Africa). 01/01/2018 - 31/12/2021

Abstract

Almost 90% of deaths from HPV-related invasive cervical cancer (ICC) worldwide occur in developing countries and ICC is a main cause of morbidity and mortality in Sub-Saharan Africa (SSA). However, in SSA, we observe a significant lack of ICC knowledge among health care workers. Furthermore, academic ICC expertise is also completely missing, undermining any effort to strengthen the health care capacities. Local academic expertise is also vital for National policy makers and public opinion. In 2013, we established the WAKA network to train African based researchers till a post-doc level, to stimulate international South South collaboration and to support local laboratory facilities (www.wakahpvafrica.com). Several students from SSA are in a doctoral trajectory and the WAKA network gained significant recognition (i.e. WHO). This proposal wants to continue, deepen and expand this network until a level of self-sustainability.

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The Belgian prenatal microarray database (BEMAPRE): realization of the database, determination of genotype-phenotype correlations and postnatal follow-up. 01/10/2016 - 30/09/2018

Abstract

In Belgium, samples for prenatal genetic diagnosis are analyzed by Chromosomal Microarray Analysis (CMA). The main challenge herein lies in the interpretation of copy number variants (CNVs) for which knowledge about postnatal outcome is limited. All Belgian genetic centers have agreed on prenatal CNV classification, but ambiguous situations still occur. The goal of our research is to 1) investigate genotype-phenotype correlations using clinical data of children with prenatally registered non-benign CNVs; 2) narrow down the prenatal genotype-phenotype correlation of frequently found known pathogenic CNVs and 3) focus on outcome in children with other than benign CNVs and renal/urogenital anomalies on ultrasound. To secure our goals, we have created a Belgian database for registration of prenatal CMA data. In the first year of my PhD, I developed the framework of this database, guided the genetic centers in importing their data and presented our first results at international conferences. Next, I will start postnatal data collection of children with other than benign CNVs, determine renal function at the age of 1 year in case of a renal/urogenital ultrasound anomaly, and assess neurologic and psychomotor development at the age of 2-3 years. By ameliorating genotype–phenotype knowledge of prenatally registered CNVs, we will develop a strong scientific base for clinical decision-making in prenatal diagnosis. This work is a collaboration of all Belgian academic genetic centers.

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Appui scientifique pour la realization du project interdisciplinaire/interuniversitaire en santé maternelle à Unikin et à Unilub 01/12/2014 - 30/11/2018

Abstract

This project represents a formal research agreement between UA and on the other hand VLIR. UA provides VLIR research results mentioned in the title of the project under the conditions as stipulated in this contract.

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