Experimental models

experimental models

  • Acute kidney injury (AKI)
  • Chronic kidney disease (CKD)
  • Kidney transplantation
  • Nephrocalcinosis
  • Vascular calcification
  • Bone loss (osteoporotic, CKD-induced)
  • Sepsis
  • Multi-organ failure

Diagnostics

diagnostics

  • Kidney injury (urine/tissue)
  • Metal and trace element analysis
  • Bone morphometry
  • Critical illness (plasma/urine)
  • Cell death and inflammation biomarkers

Mechanistic studies

mechanistic studies

  • Mineral homeostasis
  • Kidney, vessel & bone interaction
  • Vascular stiffness
  • Cell death & ferroptosis
  • Senescence & regeneration
  • Transgenics

Drug validation

drug validation

  • Vascular calcification inhibitors
  • Phosphate binders
  • Drug repurposing
  • Ferroptosis inhibitors

Clinical studies

clinical studies

  • Drug repurposing
  • Observational cohort studies