Chronic interstitial nephritis in agricultural communities is a toxin-induced proximal tubular nephropathy

Benjamin A. Vervaet, Cynthia C. Nast, Channa Jayasumana, Gerd Schreurs, Frank Roels, Chula Herath, Nika Kojc, Vahid Samaee, Sonali Rodrigo, Swarnalata Gowrishankar, Christiane Mousson, Rajeewa Dassanayake, Carlos M. Orantes, Vincent Vuiblet, Claire Rigothier, Patrick C. D’Haese, Marc E. De Broe
Kidney International 2020; 97: 350–369. DOI:

Inositol phosphate
Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers

Antonia E. Schantl,Anja Verhulst, Ellen Neven, Geert J. Behets, Patrick C. D’Haese et al.
Nature Communications 2020; 11: 721. doi: 10.1038/s41467-019-14091-4

The complex pathophysiology of cardiovascular calcification 

Learning from similarities and differences across rare- and acquired disease types.
A 2-day symposium focussing on cardiovascular calcification.
Monday and Tuesday Dec 2-3, 2019.
Grauwzusters Monastery, Antwerp, Belgium.

arterial stiffness
The Vicious Cycle between Arterial Stiffness and Arterial Media Calcification

Geoffrey Van den Bergh, Britt Opdebeeck, Patrick C. D’Haese & Anja Verhulst.
Trends in Molecular Medicine Volume 25, Issue 12, December 2019; Pages 1133-1146.

Brothers with a mission

Lectures for charity, Ruiselede 19/10/2019

Müller Cell Report 2019
Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization


  • Poly(ADP-ribose) is found close to ECM calcification in developing bone and arteries
  • Poly(ADP-ribose) is produced in response to oxidative stress and delivered to the ECM
  • Poly(ADP-ribose) forms dense liquid droplets with calcium ions
  • Inhibiting PARP enzyme activity blocks calcification in vitro and in vivo

Opdebeeck JASN
Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance

Britt Opdebeeck, Stuart Maudsley, Abdelkrim Azmi, Annelies De Maré, Wout De Leger, Bjorn Meijers, Anja Verhulst, Pieter Evenepoel, Patrick C. D’Haese and Ellen Neven.
JASN May 2019, 30 (5) 751-766; DOI:

If we just let cancer rust away

Levensloop’ - Gent 27/04/2019

Charcot Fund for multiple sclerosis research

Tom Vanden Berghe, 2019 Laureate. - Brussels, 24/01/2019

Brothers and professors in the fight against cancer

Tom and Wim Vanden Berghe, Kom op tegen kanker 2018 

Neven Kidney International 2018
Metformin prevents the development of severe chronic kidney disease and its associated mineral and bone disorder

Impact of metformin treatment on vascular calcification in adenine-induced CKD rats.
Total calcium content in the (A) aorta, (B) femoral artery, and (C) carotid artery in vehicle (n= 14) versus metformin-treated rats with chronic kidney disease (n= 13).
Von Kossa-stained sections of (D) a calcified aorta of a vehicle-treated rat and (E) an intact aorta of a metformin-treated rat. *P <0.05 versus vehicle.
Ellen Neven, Benjamin Vervaet, Kerstin Brand, Ulrike Gottwald-Hostalek, Britt Opdebeeck, Annelies De Maré, Anja Verhulst, Jean-Daniel Lalau, Said Kamel, Marc E. De Broe, Patrick C. D’Haese.
Kidney International, July 2018, Volume 94, Issue 1, Pages 102–113 DOI: