Andy Wullaert associate professor Research Andy Wullaert Research team Cell death signaling (CDS) Expertise My research group investigates the function of cytosolic protein complexes termed inflammasomes that play important roles in immune responses. Inflammasome activation happens through a sensor …

Medicinal Chemistry search menu search content Inflammation Inflammatory caspases Current work on the inflammatory caspases (mainly caspase-1) was initiated as an application of the MSAS approach discussed below. This fragment-based methodology identified several carboxylate isostere-containing buil…

Michelle Zurek predoc researcher FWO Research Michelle Zurek Research team Physiopharmacology (PHYSPHAR) The role of gasdermin E-mediated necrosis in atherosclerosis. 01/11/2023 - 31/10/2027 Abstract Cell death is a prominent feature of advanced plaques with a major impact on atherogenesis and plaqu…

Hans De Winter professor Research Hans De Winter Research team Medicinal Chemistry (UAMC) Expertise Computational chemistry Chemoinformatics Molecular modeling Computer-aided drug design Protein structure-based drug design Quantitative structure-activity relationships (QSAR) Cosolvent molecular dyna…

Cell Death Signaling search menu search content Teams Our Cell Death Signaling research group integrates following research lines: Ferroptosis Signaling - Tom Vanden Berghe The lab investigates mechanisms, diagnostics, and intervention strategies related to critical illnesses, brain injuries, kidney…

Kathleen Mertens predoc researcher FWO Publications Kathleen Mertens Dipeptidyl peptidase 9 in human leukocytes : novel inhibitors induce caspase‐1‐ and gasdermin‐dependent cell death Source European journal of immunology - ISSN 0014-2980-55:6 (2025) p. 1-17 Author(s) Joni De Loose, Kathleen M…

Pieter Van Der Veken full professor Research Pieter Van Der Veken Research team Medicinal Chemistry (UAMC) Expertise Medicinal chemistry & drug discovery, pharmaceutical chemistry, organic chemistry & organic synthesis Bench-to-bedside research into the role of regulated cell death and barrier dysfu…

Filipe Elvas TT. asst. research professor Research Filipe Elvas Research team Molecular Imaging and Radiology (MIRA) Expertise Development and validation of radiopharmaceuticals that can provide non-invasive and longitudinal whole-body diagnosis of disease and monitoring of therapeutic responses usi…

Sigrid Stroobants full professor Research Sigrid Stroobants Research team Molecular Imaging and Radiology (MIRA) Alliance for multidimensional and multidisciplinary neuroscience (µNEURO). 01/01/2026 - 31/12/2031 Abstract Owing to their high spatiotemporal resolution and non-invasive nature, (bio)me…

Anne-Marie Lambeir emeritus occasional assignment Publications Anne-Marie Lambeir Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic poten…

Nicolò Filippi unpaid staff Publications Nicolò Filippi Dipeptidyl peptidase 9 in human leukocytes : novel inhibitors induce caspase‐1‐ and gasdermin‐dependent cell death Source European journal of immunology - ISSN 0014-2980-55:6 (2025) p. 1-17 Author(s) Joni De Loose, Kathleen Mertens, Nic…

Karuna Adhikari senior researcher Publications Karuna Adhikari Synthesis and preclinical evaluation of druglike ¹⁸F-labeled fibroblast activation protein (FAP) inhibitors with enhanced tumor retention Source Bioconjugate chemistry - ISSN 1043-1802-36:8 (2025) p. 1887-1906 Author(s) Karuna Adhikar…

Andy Wullaert associate professor Publications Andy Wullaert Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice Source Trends in immunology - ISSN 1471-4906-46:10 (2025) p. 662-665 Author(s) Hannah Stocks, Jolien Van Cleemput, Linos Vandekerckhove, Andy Wullaert Citation link Pyrin inflam…

Joni De Loose unpaid staff Publications Joni De Loose Fibroblast activation protein on human natural killer cells : insights from natural killer cell activation and crosstalk with cancer-associated fibroblasts Source Journal of leukocyte biology - ISSN 1938-3673-117:7 (2025) p. 1-18 Author(s) Yentl …

Siham Benramdane expert Publications Siham Benramdane Dipeptidyl peptidase 9 in human leukocytes : novel inhibitors induce caspase‐1‐ and gasdermin‐dependent cell death Source European journal of immunology - ISSN 0014-2980-55:6 (2025) p. 1-17 Author(s) Joni De Loose, Kathleen Mertens, Nicolò…

Ingrid De Meester full professor Publications Ingrid De Meester Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potential Source Journa…

Maya Berg senior research manager Publications Maya Berg Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potential Source Journal of me…

Pieter Van Der Veken full professor Publications Pieter Van Der Veken Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potential Source …

Integrated Personalized and Precision Oncology Network search menu search content IPPON Centre of Excellence Our mission The research activities of the IPPON consortium are at the forefront of integrated personalized cancer medicine. For different cancers in urgent need for improved therapeutic outc…

Silke Mortelmans doctoral scholarship holder Research Silke Mortelmans Research team Cell death signaling (CDS) Investigating the impact of inflammasome-induced pyroptosis on visceral leishmaniasis in mice. 01/10/2022 - 30/09/2026 Abstract The Nlrp3 inflammasome is a protein complex that responds to…

Yentl Van Rymenant unpaid staff Publications Yentl Van Rymenant Synthesis and preclinical evaluation of druglike ¹⁸F-labeled fibroblast activation protein (FAP) inhibitors with enhanced tumor retention Source Bioconjugate chemistry - ISSN 1043-1802-36:8 (2025) p. 1887-1906 Author(s) Karuna Adhika…

Sam Corthaut researcher Publications Sam Corthaut Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potential Source Journal of medicinal…

Yani Sim spec. staff member - expert Publications Yani Sim Dipeptidyl peptidase 9 in human leukocytes : novel inhibitors induce caspase‐1‐ and gasdermin‐dependent cell death Source European journal of immunology - ISSN 0014-2980-55:6 (2025) p. 1-17 Author(s) Joni De Loose, Kathleen Mertens, Ni…

Molecular Imaging and Radiology (MIRA) search menu search content Projects Ongoing projects Belgian MR Research Community (MaRBEL). 01/01/2025 - 31/12/2029 Abstract MaRBEL brings the Belgian MR research landscape to the forefront by connecting MRI researchers within Belgium to each other, facilitati…

Koen Augustyns full professor Research Koen Augustyns Research team Medicinal Chemistry (UAMC) Expertise Koen Augustyns (°13/09/1965) obtained his Master and PhD in Pharmaceutical Sciences at the KU Leuven, Belgium in 1988 and 1992 respectively. After postdoctoral stays at the University of Antwerp…