Andy Wullaert associate professor Research Andy Wullaert Research team Cell death signaling (CDS) Expertise My research group investigates the function of cytosolic protein complexes termed inflammasomes that play important roles in immune responses. Inflammasome activation happens through a sensor …

Louis Lauwerys doctoral scholarship holder Research Louis Lauwerys Research team Molecular Imaging and Radiology (MIRA) Development of novel caspase-3 PET radiotracers for imaging immunotherapy responses. 01/10/2021 - 30/09/2025 Abstract Caspases are well known for their role as executioners of apop…

Michelle Zurek predoc researcher FWO Research Michelle Zurek Research team Physiopharmacology (PHYSPHAR) The role of gasdermin E-mediated necrosis in atherosclerosis. 01/11/2023 - 31/10/2025 Abstract Cell death is a prominent feature of advanced plaques with a major impact on atherogenesis and plaqu…

Medicinal Chemistry search menu search content Inflammation Inflammatory caspases Current work on the inflammatory caspases (mainly caspase-1) was initiated as an application of the MSAS approach discussed below. This fragment-based methodology identified several carboxylate isostere-containing buil…

Hans De Winter professor Research Hans De Winter Research team Medicinal Chemistry (UAMC) Expertise Computational chemistry Chemoinformatics Molecular modeling Computer-aided drug design Protein structure-based drug design Quantitative structure-activity relationships (QSAR) CalcUA 01/01/2022 - 31/1…

Cell Death Signaling search menu search content Teams Our Cell Death Signaling research group integrates following research lines: Ferroptosis Signaling - Tom Vanden Berghe The lab investigates mechanisms, diagnostics, and intervention strategies related to critical illnesses, brain injuries, kidney…

Pieter Van Der Veken full professor Research Pieter Van Der Veken Research team Medicinal Chemistry (UAMC) Expertise Medicinal chemistry & drug discovery, pharmaceutical chemistry, organic chemistry & organic synthesis Bench-to-bedside research into the role of regulated cell death and barrier dysfu…

Filipe Elvas TT. asst. research professor Research Filipe Elvas Research team Molecular Imaging and Radiology (MIRA) Expertise Development and validation of radiopharmaceuticals that can provide non-invasive and longitudinal whole-body diagnosis of disease and monitoring of therapeutic responses usi…

Karuna Adhikari senior researcher Publications Karuna Adhikari Development of caspase-3-selective activity-based probes for PET imaging of apoptosis Source EJNMMI Radiopharmacy and Chemistry - ISSN 2365-421X-9:1 (2024) p. 1-26 Author(s) Louis Lauwerys, Lucas Beroske, Angelo Solania, Christel Vangest…

Andy Wullaert associate professor Publications Andy Wullaert Development of human innate immune responses in a humanized mouse model expressing four human myelopoiesis transgenes Source Frontiers in immunology - ISSN 1664-3224-15 (2024) p. 1-15 Author(s) Hannah Stocks, Elisabeth De Leeuw, Bart N. La…

Filipe Elvas TT. asst. research professor Publications Filipe Elvas Astatine-211 radiolabelling chemistry : from basics to advanced biological applications Source EJNMMI Radiopharmacy and Chemistry - ISSN 2365-421X-9:1 (2024) p. 1-57 Author(s) Maarten Vanermen, Mathilde Ligeour, Maria-Cristina Olive…

Anne-Marie Lambeir emeritus occasional assignment Publications Anne-Marie Lambeir Development of caspase-3-selective activity-based probes for PET imaging of apoptosis Source EJNMMI Radiopharmacy and Chemistry - ISSN 2365-421X-9:1 (2024) p. 1-26 Author(s) Louis Lauwerys, Lucas Beroske, Angelo Solani…

Christel Vangestel unpaid staff Publications Christel Vangestel Development of caspase-3-selective activity-based probes for PET imaging of apoptosis Source EJNMMI Radiopharmacy and Chemistry - ISSN 2365-421X-9:1 (2024) p. 1-26 Author(s) Louis Lauwerys, Lucas Beroske, Angelo Solania, Christel Vanges…

Alan Miranda Menchaca senior researcher Publications Alan Miranda Menchaca Preclinical evaluation of the novel [¹⁸F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington's disease Source European journal of nuclear medicine and molecular imaging - ISSN …

Sigrid Stroobants full professor Research Sigrid Stroobants Research team Molecular Imaging and Radiology (MIRA) Alliance for multidimensional and multidisciplinary neuroscience (µNEURO). 01/01/2026 - 31/12/2031 Abstract Owing to their high spatiotemporal resolution and non-invasive nature, (bio)me…

Pieter Van Der Veken full professor Publications Pieter Van Der Veken Computational study of DPP8 and DPP9 : fundamental insights and inhibitor design Source Antwerp, University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Department of Pharmaceutical Sciences, 2024,242…

Molecular Imaging and Radiology (MIRA) search menu search content Projects Ongoing projects Optimized theranostic tools for personalized medicine. 01/11/2024 - 31/10/2026 Abstract Cancer-associated fibroblasts (CAFs) are a group of tumor stromal cells typically associated with cancer growth and meta…

Koen Augustyns full professor Research Koen Augustyns Research team Medicinal Chemistry (UAMC) Expertise Koen Augustyns (°13/09/1965) obtained his Master and PhD in Pharmaceutical Sciences at the KU Leuven, Belgium in 1988 and 1992 respectively. After postdoctoral stays at the University of Antwerp…

Silke Mortelmans doctoral scholarship holder Research Silke Mortelmans Research team Cell death signaling (CDS) Investigating the impact of inflammasome-induced pyroptosis on visceral leishmaniasis in mice. 01/10/2022 - 30/09/2026 Abstract The Nlrp3 inflammasome is a protein complex that responds to…

Medical Biochemistry search menu search content Key publications Biophysical analysis of the membrane-proximal Venus Flytrap domain of ESAG4 receptor-like adenylate cyclase from Trypanosoma brucei Source Molecular and biochemical parasitology - ISSN 0166-6851- (2024) p. Author(s) Desirée O. Alves, …

Medicinal Chemistry search menu search content Projects Ongoing projects Development of chemical tools for deciphering the virulent roles of Streptococcus pneumoniae HtrA protease. 01/10/2024 - 30/09/2027 Abstract Streptococcus pneumoniae (SP) is a leading cause of community-acquired pneumonia, with…

Integrated Personalized and Precision Oncology Network search menu search content IPPON Centre of Excellence Our mission The research activities of the IPPON consortium are at the forefront of integrated personalized cancer medicine. For different cancers in urgent need for improved therapeutic outc…

Laboratory of Cell Biology and Histology search menu search content Cell biology of cancer and neurodegeneration/aging Accelerated Aging Diseases Running research topics: Progeroid disorders Laminopathies are genetic diseases that target specific tissues such as adipose, muscle or nerves, but can al…

Joseph Merregaert emeritus occasional assignment Research Joseph Merregaert Research team Expertise Generation of trangenic mouse lines (overexpression, knock-out, knock-in). Protective effect of the extracellular matrix protein 1 (ECM1) against epidermal basement membrane damage: proof of concept. …

Margarida Florindo Espadinha senior researcher Research Margarida Florindo Espadinha Research team Medicinal Chemistry (UAMC) DPP9 degradation-induced pyroptosis for treatment of acute myeloid leukemia (DPP9-TACDrug). 01/04/2023 - 31/03/2025 Abstract Dipeptidyl-peptidase 9 (DPP9) is a proline-select…