5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein-Protein Interaction-Derived Functions

Source
Journal of medicinal chemistry - ISSN 0022-2623
Author(s)
    Henri T. Patsi, Tommi P. Kilpelainen, Mikael Jumppanen, Johanna Uhari-Vaananen, Pieter Van Wielendaele, Francesca De Lorenzo, Hengjing Cui, Samuli Auno, Janne Saharinen, Erin Seppala, Nina Sipari, Juha Savinainen, Ingrid De Meester, Anne-Marie Lambeir, Maija Lahtela-Kakkonen, Timo T. Myohanen, Erik A. A. Wallen

Chemically diverse activity-based probes with unexpected inhibitory mechanisms targeting trypsin-like serine proteases

Source
Frontiers in Chemistry - ISSN 2296-2646-10 (2023) p. 1-17
Author(s)