Microorganisms have been exploited from the earliest times for baking, brewing, and food preservation. More recently, the enormous versatility in biochemical and physiological properties of microbes has been exploited to create new chemicals and nanomaterials, and has led to bio-electrical systems employed for clean energy and waste management. Moreover, it has become clear that humans, animals and plants are greatly influenced by their microbiome, leading to new medical treatments and agricultural applications. Recent progress in molecular biology and genetic engineering provide a window of opportunity for developing new microbiology-based technology. Just as advances in physics and engineering transformed life in the 20th century, rapid progress in (micro)biology is poised to change the world in the decades to come. The Excellence Centre "Microbial Systems Technology" (MST) will assemble and consolidate the expertise in microbial ecology and technology at UAntwerpen, embracing state-of-the-art technologies and interdisciplinary systems biology approaches to better understand microbes and their environment and foster the development of transformational technologies and applications. MST connects recently established research lines across UAntwerpen in the fields of microbial ecology, medical microbial ecology, plant physiology, biomaterials and nanotechnology with essential expertise in Next Generation Sequencing and Bioinformatics. By joining forces, new and exciting developments can be more quickly integrated into research activities, thus catalyzing the development of novel microbial products and processes, including functional food, feed and fertilizers, probiotics, and novel biosensors and bio-electronics applications. This way, MST aims for an essential contribution to the sustainable improvement of human health and the environment.