Scientific Chair Nephrology.
Abstract
This project represents a formal research agreement between UA and on the other hand a private institution. UA provides the private institution research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Verpooten Gert
Research team(s)
Project type(s)
- Research Project
Chronic kidney disease and cardiovascular risk: endothelial dysfunction at the interface?
Abstract
In the present project, we focus on endothelial dysfunction in CKD patients. Endothelial dysfunction precedes overt atherosclerotic changes of the vascular wall by many years. Interestingly, in the absence of structural changes, endothelial dysfunction is still reversible, which offers therapeutic perspectives to tackle the progression towards atherosclerosis in an early stage. Several mechanisms for the development of endothelial dysfunction will be investigated, with special emphasize on mechanisms that repair the vascular wall. Moreover, we will study the possible beneficial effect of physical exercise on endothelial function in CKD patients.Researcher(s)
- Promoter: Verpooten Gert
- Co-promoter: Conraads Viviane
- Co-promoter: Vrints Christiaan
- Fellow: Van Craenenbroeck Amaryllis
Research team(s)
Project type(s)
- Research Project
Pharmaco-epidemiological research on the relationship between drug interactions and polypharmacy based on data from the database Farmanet.
Abstract
Researcher(s)
- Promoter: Jorens Philippe
- Co-promoter: Verpooten Gert
Research team(s)
Project type(s)
- Research Project
BOF - University Research Fund: 1 year doctoral fellowship in view of a second IWT application (Kristien Ledeganck).
Abstract
Researcher(s)
- Promoter: Verpooten Gert
- Fellow: Ledeganck Kristien
Research team(s)
Project type(s)
- Research Project
Expression of genes involved in inflammation and fibrosis in protocolbiopsies of renal allografts. A study of the pathophysiologic mechanisms of chronic allograft nephropathy.
Abstract
In a prospective, randomized study in de novo kidney transplant recipients, we will compare the influence of a combination therapy with prednisolone, mycophenolate mofetil, and cyclosporine with a combination therapy with prednisolone, mycophenolate mofetil, and rapamycine, on the expression of genes, associated with inflammation and fibrosis in protocol biopsies of the graft, six months after transplantation. Glomeruli, tubulo-epithelial cells and interstitial cells will be isolated by means of the laser capture microscope. After RNA-extraction, we will perform semiquantitative RT amplification with Taqman PCR for the genes of interest: i.e. IL 10, IL 12, TNF alpha, B7-1, B7-RP1, CD40, CXCR3, CCR5, perforine, granzyme, angiotensine II, TGF-ß1, PAI-1, TIMP-1, and endotheline.Researcher(s)
- Promoter: Bosmans Jean-Louis
- Co-promoter: Bogers John-Paul
- Co-promoter: De Broe Marc
- Co-promoter: Van Rompay An
- Co-promoter: Verpooten Gert
- Co-promoter: Ysebaert Dirk
Research team(s)
Project type(s)
- Research Project
The plasminogen activator/plasmin system in the kidney and cyclosporine nephrotoxicity.
Abstract
The different elements of the plasminogen activator/plasmin system are determined in rat kidney using biochemical and immunohistochemical techniques. Furthermore, the influence of cyclosporine in the system is studied.Researcher(s)
- Promoter: Verpooten Gert
- Fellow: Duymelinck Carla
Research team(s)
Project type(s)
- Research Project
A prospective clinical and experimental study of the effects of blood lipid disturbances and cytomegalovirus infection on the development of chronic cyclosporine toxicity.
Abstract
Blood lipid disturbances and cytomegalovirus infections will be prospectively monitored in renal transplant recipients. The renal lesions induced by cyclosporine will be evaluated in a renal biopsy and related to the metabolic and clinical events.Researcher(s)
- Promoter: Verpooten Gert
- Co-promoter: Nouwen Etienne
- Co-promoter: Van Hoof Viviane O M
Research team(s)
Project type(s)
- Research Project
The plasminogen activator/plasmin system in the kidney and cyclosporine nephrotoxicity.
Abstract
The plasmin system is a proteolytic system involved in the development of fibrosis, which is an important feature of cyclosporine nephrotoxicity. In a rat model of cyclosporine nephrotoxicity, the activity of the plasmin system is downregulated by the increased expression of the plasminogen activatior inhibitor.Researcher(s)
- Promoter: Verpooten Gert
- Fellow: Duymelinck Carla
Research team(s)
Project type(s)
- Research Project
The role of growth factors in the initiation of chronic cyclosporine nephrotoxicity
Abstract
Chronic cyclosporine nephrotoxicity is characterized by renal interstitial cellular infiltration and fibrosis... In a rat model the pathogenesis of this disorder is investigated by means of immunochemical characterisation of the infiltrating cells and by Northern analysis of the mRNA expression of growth factors and cytokines.Researcher(s)
- Promoter: Verpooten Gert
Research team(s)
Project type(s)
- Research Project
The role of growth factors in the development of the renal fibrosis of chronic cyclosporine nephrotoxicity.
Abstract
Cyclosporine is one of the basic therapies after kidney-, heart- and liver transplantation and is also used for the treatment of systemic diseases, but is toxic for the kidney. We will try to find an answer to the following question : which growth factors play a role in the initiation and development of interstitial fibrosis in the kidney during chronic cyclosporine administration. An experimental animal model will be used.Researcher(s)
- Promoter: De Broe Marc
- Fellow: Verpooten Gert
Research team(s)
Project type(s)
- Research Project