Glenn A L Van Den Bosch guest professor

Research Glenn A L Van Den Bosch

Research team

Development of an HIV vaccine using dendritic cells transfected with mRNA encoding HIV antigens. 01/10/2003 - 30/09/2005

Abstract

The aim of the project is to induce a strong HIV-specific T-cell response, through loading of antigen-presenting cells (APC), more specific dendritic cells (DC) with Tat and/or Rev antigens, possibly in combination with Gag messenger RNA (mRNA). The ex vivo loading of autologous DC with Tat and/or Rev allows us to optimize the antigen dose, the DC type and the antigen loading method. Moreover, this method permits us to study the role of HIV-specific CD4+ Th1 cells at the induction and sustaining of a HIV-specific CTL effector response in vitro, at which CTL-mediated lysis of infected cells and eradication of the virus can be set as an endpoint.

Researcher(s)

Research team(s)

    Project type(s)

    • Research Project

    Development of an HIV vaccine using dendritic cells transfected with mRNA encoding HIV antigens. 01/10/2001 - 30/09/2003

    Abstract

    The aim of the project is to induce a strong HIV-specific T-cell response, through loading of antigen-presenting cells (APC), more specific dendritic cells (DC) with Tat and/or Rev antigens, possibly in combination with Gag messenger RNA (mRNA). The ex vivo loading of autologous DC with Tat and/or Rev allows us to optimize the antigen dose, the DC type and the antigen loading method. Moreover, this method permits us to study the role of HIV-specific CD4+ Th1 cells at the induction and sustaining of a HIV-specific CTL effector response in vitro, at which CTL-mediated lysis of infected cells and eradication of the virus can be set as an endpoint.

    Researcher(s)

    Research team(s)

      Project type(s)

      • Research Project