Research team
Expertise
Sensor development for the determination of organic ionic substances.
Development of technology within the "label free detection systems" technology platform for the fast and accurate detection of small molecules
Abstract
The project aims at supporting the claims of two UAntwerp patents. The technology protected by these patents offer an alternative to "label free detection systems" on the market today, and cover a new platform for fast and accurate detection of selected small molecules.Researcher(s)
- Promoter: De Wael Karolien
- Co-promoter: Blust Ronny
- Co-promoter: Nagels Luc
- Co-promoter: Van Camp Guy
Research team(s)
Project type(s)
- Research Project
Development of a coated-wire potentiometric sensor for detection of DNA variants and mutations
Abstract
In human genetic diagnostics, there is a large need for instruments that can detect DNA variants and mutations efficiently and cost-effectively. Current fluorescent methods are expensive and often not suitable for extended multiplex analysis. The aim of this study is the development of a potentiometric coated wire sensor that is able to reliably and quickly detect DNA variants, by adapting a successful sensor platform that has been developed previously at the University of Antwerp.Researcher(s)
- Promoter: Van Camp Guy
- Co-promoter: Nagels Luc
Research team(s)
Project type(s)
- Research Project
Chromatographic Organic Trace Analysis.
Abstract
A potentiometric sensor is made for the specific detection of an oligonucleotide. The mutation which causes mucoviscidosis is taken as an example. The potentiometric sensor has a PVC/plasticizer rubber coating on a metal conductor. The PVC is aminated, and the oligonucleotide is coupled to the surface via UV irradiation. We then study the interaction of match and mismatch oligonucleotides with the sensor. The sensor should respond selectively to the target oligonucleotide. We then study the possibility to use the sensor in real-time PCR experiments.Researcher(s)
- Promoter: Nagels Luc
Research team(s)
Project type(s)
- Research Project
Interaction of large biomolecules with potentiometric sensor surfaces.
Abstract
The research group studies the use of potentiometric sensors for the determination of organic charged molecules. Recently, work was done on large biomolecules such as oligonucleotides and phosphoproteins. In the present project, we will develop a method to study the kinetics of interaction (adsorption/desorption) of these products with the sensor surface, via FIA and sensorgrams.Researcher(s)
- Promoter: Nagels Luc
Research team(s)
Project type(s)
- Research Project
Impedance spectroscopy for sensor development.
Abstract
The target of this project is the introduction of impedance spectroscopy in the department IWT of the KDG and in the UA research group: "Chromatografische organische sporenanalyse" for the development of potentiometric sensors. This technique gives us insight in the different processes that occur during potential buildup (mass transport, diffusion, ion-electron conversion, ¿). This information will result in a more effective development of the potentiometric electrodes.Researcher(s)
- Promoter: Nagels Luc
Research team(s)
Project type(s)
- Research Project
High throughput screening of nanocomposite sensor materials for the determination of ionic organic substances.
Abstract
The aim of the project is to make sensor materials with which we can determine organic ionic substances with low logP values. We will use hydrophilic polymers which are based on segmented networks with butylacrylate and poly-ethyleneoxide as a basis. To make these polymers ionically conductive, we will use MM and NaY materials, embedded as nanocomposites. The testset for the low logP products will be mainly composed of a set of 25 basic pharmaceutical drugs. To increase the selectivity for a certain drug, neutral receptor molecules of the calixarene type will be used.Researcher(s)
- Promoter: Nagels Luc
Research team(s)
Project type(s)
- Research Project
Development of thin film potentiometric sensors for dissolution testing.
Abstract
The aim of the project is to develop a general purpose sensor, based on surface potential development, which can measure dissolution of pharmaceutical drugs on-line.Researcher(s)
- Promoter: Nagels Luc
Research team(s)
Project type(s)
- Research Project
Dissolution Project Plan.
Abstract
To determine the dissolution properties of medical substances on the basis of potentiometric sensors.Researcher(s)
- Promoter: Nagels Luc
Research team(s)
Project type(s)
- Research Project
Dissolution Project Plan.
Abstract
Dissolution testing is very important for pharmaceutical companies. The present apparatus is directed to spectroscopic methods. These methods have a large number of disadvantages. Our group develops potentiometric sensors to monitor dissolution kinetics of basic drugs in pharmaceutical formulations. New types of electrodematerials are tested. The nature of these materials is not revealed as they are being patented.Researcher(s)
- Promoter: Nagels Luc
Research team(s)
Project type(s)
- Research Project
Abstract
This project "Bridge to innovation", aims to ripen a scientific idea to make a bigger industrial project. It concerns a sensor for HPLC and for dissolution testing.Researcher(s)
- Promoter: Nagels Luc
Research team(s)
Project type(s)
- Research Project
Synthesis of polymeric membranes for use in potentiometric detection of organic ionic substances with LC.
Abstract
New electrode coating materials (ionically conducting plastics in the rubber phase)will be tested for use in an organic ions sensor.Researcher(s)
- Promoter: Nagels Luc
Research team(s)
Project type(s)
- Research Project
Abstract
Macrocyclic ionophores (hexaazamacrocycles) were tested for the determination of organic acids with potentiometry besed sensors.Researcher(s)
- Promoter: Nagels Luc
- Fellow: Zielinska Danuta
Research team(s)
Project type(s)
- Research Project
Synthesis of potentiometric microelectrodes for use in CE, via chemical modification of electrochemically deposited "coated wire" electrodes.
Abstract
During the last years, the research group developed interesting potentiometric electrodes for the sensitive determination of biochemically important organic substances via CE and LC. The most succesfull types were of the "liquid membrane" type. Conductive polymers als performed well and are the more interesting coating materials, but their reproducibility has been unsatisfactory. The new project aims to develop a totally new type of electrode material, based on conductive polymers.Researcher(s)
- Promoter: Nagels Luc
Research team(s)
Project type(s)
- Research Project
Abstract
Researcher(s)
- Promoter: Nagels Luc
- Fellow: Denkens Dolf
Research team(s)
Project type(s)
- Research Project
Conductive polymers for the amperometric and potentiometric detection of non-electroactive substances in LC and CE methods.
Testing a macrocyclic host molecule in a potentiometric coated wire detector for the determination of biochemically important organic acids with HPLC.
Abstract
A macrocyclic hexamine was synthesized as a "host" molecule for biochemically important organic acids. This hexamine will now be tested in a "coated wire" potentiometric electrode. It serves as an ionophore, for the optimization of the potentiometric detection of these organic acids in an HPLC system. Conducting polymers or oligomers are used in the coating material.Researcher(s)
- Promoter: Nagels Luc
- Fellow: Zielinska Danuta
Research team(s)
Project type(s)
- Research Project
Abstract
Researcher(s)
- Promoter: Nagels Luc
- Fellow: Poels Ilse
Research team(s)
Project type(s)
- Research Project
Development of new electrode materials for amperometric HPLC detectors.
Abstract
In this project is checked in how far some new conducting materials can be envisaged as electrode materials for electrochemical detectors (ECD). It concerns poly(p-phenylene) products. The materials are chosen as such that they can be produced, in a reproducable manner, by means of coating techniques. This project is limited to coatings with conducting doped polymers.Researcher(s)
- Promoter: Nagels Luc
Research team(s)
Project type(s)
- Research Project