I am a clinical geneticist, participating in both patient care and research. As a clinician, I am specialized in (pediatric) neurogenetics, brain developmental disorders and dysmorphology. As a researcher, my main focus points are cerebral palsy and cerebrovascular disorders. Unraveling the molecular basis of cerebrovascular disorders was already the topic of my PhD research.
Cerebral palsy (CP) is a group of non-progressive, permanent motor disorders, caused by a brain abnormality that originates around birth, that are frequently associated with (neurological) comorbidities, e.g. developmental delay and autism. Birth hypoxia, the best-known cause of CP, is shown to play a role in only <10% of cases, while genetic causes are increasingly demonstrated. Cerebrovascular abnormalities, including cerebral hemorrhage or infaction, are present in some CP patients. With my research, I aim to indentify novel genetic causes and pathways contributing to CP. This work is in close collaboration with the Dept. of Pediatric Neurology of the UZA.
In addition to the pediatric population, I also study genetic causes of cerebrovascular disorders in adults, with a focus on intracranial aneurysms. Intracranial aneurysms are local dilatations of cerebral arteries with an increased chance of rupture of the vessel wall, leading to subarachnoidal hemorrhage and subsequent major patient morbidities and mortality. This research is performed in close collaboration with the Neurovascular Center Antwerp (NVCA) of the UZA.
Statute & functions
Zelfstandig academisch pers.
- Assistant Professor