ATCR Previous editions

Day 1 (May 3rd, 2023)

• 0815: Registration and coffee
• 0830: Primer on TCR science by Pieter Meysman (Belgium)
• 0900: Welcome by Pieter Meysman & Benson Ogunjimi
• 0910: Opening keynote presentation by Paul G Thomas (USA) - Deconstructing the form and function of T cell responses to infections and tumors

Session 1: TCR theory, data modeling & tools

• 1000: Victor Greiff (Norway) - ​Benchmarking computational adaptive immune receptor repertoire profiling
• 1040: Romi Van Doren (University of Antwerp) - Unraveling the complex TCR-microbiome interaction network in the colon
• 1100: break

Session 2: TCR applications

• 1120: Nicole La Gruta (Australia) - Revisiting the role of Lck-coreceptor association in TCR repertoire development and immune selection
• 1200: Eva Lion (Belgium) - Chasing T cells ex vivo, in vitro and in silico: TCR functionality, signature and engineering
• 1240: Grigorii Nos (Technical University of Denmark) - Exploring the phenotype and antigen specificity of engrafting CD8 T cell clones in patients undergoing adoptive cell therapy
• 1300: lunch

Session 3: TCR theory, data modeling & tools

• 1400: Phil Bradley (USA) - Leveraging deep neural networks for structure-based prediction of TCR:peptide-MHC interactions
• 1440: Aleksandra Walczak (France) - Convergence of immune repertoires
• 1520: Marius Messemaker (The Netherlands Cancer Institute) - STAPLER: Efficient learning of TCR-peptide specificity prediction from full-length TCR-peptide data
• 1540: break & poster session

Session 4: TCR applications

• 1600: Femke Van Wijk (The Netherlands) - Human T cells in time and space
• 1640: Benson Ogunjimi (Belgium) - TCRs matter in controlling viral reactivation
• 1720: Juan L. Melero (Omniscope) - Quantification of brain metastasis-infiltrating T cells in blood using ultra-deep single-cell T cell repertoire sequencing
• 1740: Hannah van Dijk (DKFZ Heidelberg) - Characterization of the human CD8 T cell response to vaccination with the malaria vaccine target Plasmodium falciparum circumsporozoite protein
• 1800: End of scientific session day 1

18:30-2200: Walking dinner (Horta, Antwerp)

Day 2 (May 4th, 2023)

Session 5: TCR theory, data modeling & tools

• 0830: Registration
• 0900: Thierry Mora (France) - ​Response in immune repertoires
• 0940: Maria Martinez (Switzerland) - ​Interpretable deep learning for cancer personalized medicine
• 1020: Olga Lyudovyk (Cornell University) - Deep learning model to study T-cell mediated response to emerging COVID-19 strains
• 1040: break 

Session 6: TCR applications

• 1100: Diether Lambrechts (Belgium) - Single-cell characterisation of T-cell expansion during checkpoint immunotherapy
• 1140: Sabrina Pollastro (Sanquin Research) -  Monitoring birch pollen-specific CD4 T cell responses during immunomodulatory treatment
• 1200: Kerry Mullan (University of Antwerp) - STEGO.R for (easy) interrogation of combined scTCR repertoire and scRNA-seq data
• 1220: 10x Genomics sponsored talk: Barcode Enabled Antigen Mapping (BEAM): Multiplexed Antigen screening at single cell resolution
• 1225: lunch

Session 7: TCR theory, data modeling & tools

• 1330: Andreas Mayer (UK) - Measures of epitope binding degeneracy from T cell receptor repertoires 
• 1410: Morten Nielsen (Denmark) - Prediction of TCR-pMHC interactions: recent updates
• 1450: Giancarlo Croce (University of Lausanne) - Deep learning predictions of TCR specificity reveal functional chains in dual-alpha T cells
• 1510: break & poster session

Session 8: TCR applications

• 1530: Hedda Wardemann (Germany) - Functional TCR repertoire analysis after vaccination in humans
• 1610: Petra Bacher (Germany) - Modulation of human CD4+ T cell response by antigen specificity and cross-reactivity
• 1650: Koshlan Mayer-Blackwell (Fred Hutchinson Cancer Center) - Multimodal TCR sequencing design for characterizing T cell responses to mRNA vaccination in adults previously infected with SARS-CoV-2
• 1710: Alexandra Vujkovic (Institute for Tropical Medicine) - The diagnostic potential of activated CD8+ T cells during acute COVID-19
• 1730: meeting closure & end of ATCR23 by Pieter Meysman & Benson Ogunjimi

Last update: 2 May, 2023

Monday 9 December 2019

8.30-9.00: Registration

9.00-9.10: Opening of the meeting by Prof. Benson Ogunjimi

9.10-10.10: Keynote by Dr. Sarina Ravens (Hannover Medical School, Germany)γδTCR repertoires in health and disease

10.10-10.40: break

10.40-11.20: Talk by Dr. Pieter Meysman (University of Antwerp, Belgium)The T-cell receptor repertoire and vaccination

11.20-11.40: Submitted talk by Artem Mikelov (Skolkovo Institute of Science and Technology, Russia):Seasonal Dynamics In CD4 T-Cell Receptor Repertoires In Birch Pollen Allergy

11.40-12.00: Submitted talk by Sofie Gielis (University of Antwerp, Belgium):Detection of enriched T cell epitope specificity in full T cell receptor sequence repertoires

12.00-14.00: Lunch and main poster session

14.00-15.00: Keynote by Dr. Mikhail Shugay (Skolkovo Institute, Russia)VDJdb database: recent advances and potential applications

15.00-15.20: Submitted talk by Peter de Greef (Utrecht University, The Netherlands):The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes

15.20-15.50: break

15.50-16.10: Submitted talk by Chris Allen (Clinical Oncology, EMEA):Haplotype Analysis of the T-Cell Receptor Beta (TCRB) Locus by Long-amplicon TCRB Repertoire Sequencing

16.10-17:10: Keynote by Prof. Victor Greiff (University of Oslo, Norway)Comparison of immune receptors on the repertoire and sequence level

17.10-17.20: Day one closing announcements

Tuesday 10 December 2019

9:00-10:00: Keynote by Prof. Paul Thomas (St. Jude’s Children’s Hospital, USA)TCR specificity in tissues and tumors

10:00–10:30: Talk by Ayse Bassez (KULeuven, Belgium)Single-cell RNA- and T cell receptor (TCR)- sequencing to interrogate the impact of immunotherapy on the tumor microenvironment (TME)

10.30-11.00: break

11.00-11.20: Submitted talk by Pieter Moris (University of Antwerp, Belgium):Treating biomolecular binding as an image classification problem, as applied to T-cell receptor epitope recognition

11.20-11.40: Submitted talk by Li Xue (Radboudumc, The Netherlands):Fast and reliable 3D modelling of peptide:MHC class I complexes

11.40-12.40: Keynote by Prof. Aridaman Pandit (UMC Utrecht, The Netherlands)TCR repertoire dynamics in inflammatory diseases

12.40-13.40: Lunch

13.40-14.00: Meeting closing

On the 12th of December 2018, Audacis organised the first Antwerp TCR meeting.

Practical info

• Date: 12 December 2018
• Venue: UAntwerp, Hof van Liere, Prinsstraat 13, Antwerp
• F. de Tassiszaal (2nd floor)
• A. Dürerzaal (2nd floor)
• Doors open at 08:30
• Registration is closed

Programme

• 08.30-09.00: Registration
• 09.00-09.10: Benson Ogunjimi (Antwerp) – Welcome
• 09.10-10.00: Paul Thomas (Memphis)- T cell receptors and the limits of specificity
• 10.00-10.40: Phil Bradley (Seattle)- 3D structure-based approaches to T cell repertoire analysis
• 10.40-11.10: break
• 11.10-11.50: Victor Greiff (Oslo)- Pattern detection in immune repertoires
• 11.50-12.30: Pieter Meysman (Antwerp) - Supervised and unsupervised epitope-specificity learning for TCR sequences
• 12.30-13.00: Leon Eyrich Jessen (Lyngby) - Prediction models for TCR-pMHC interactions
• 13.00-14.00: Lunch
• 14.00-14.30: Wouter Scheper (Amsterdam) - Low and variable tumor-reactivity of the intratumoral TCR repertoire in human cancers
• 14.30-15.00: Lisanne Lutter (Utrecht) - Juvenile Idiopathic Arthritis: T cell clones in time and space
• 15.00-15.30: Pieter Peeters (Beersel) - Immune Repertoire Analysis in Rheumatoid Arthritis
• 15.30-16.00: break
• 16.00-16.30: Viggo Van Tendeloo (Antwerp) - TCR engineering in oncology
• 16.30-17.00: David Vermijlen (Brussels) - Insight into the development of human gammadelta T cells by high-throughput TCR/CDR3 sequencing