Murat Akkurt Arslan, Ghislaine Rabut, Solenne Chardonnet, Cédric Pionneau, Alfred Kobal, Marilyne Gratas Pelletier, Nouara Harfouche, Annabelle Réaux La Goazigo, Christophe Baudouin, Françoise Brignole-Baudouin, Karima Kessal. Expanded biochemical analyses of human tear fluid: Polyvalent faces of the schirmer strip. Experimental Eye Research. Vol. 237, December 2023, 109679. DOI: 10.1016/j.exer.2023.109679. Open Access.

Murat Akkurt Arslan, Françoise Brignole-Baudouin, Solenne Chardonnet, Cédric Pionneau, Frédéric Blond, Christophe Baudouin & Karima Kessal. Profiling tear film enzymes reveals major metabolic pathways involved in the homeostasis of the ocular surface. Scientific Reports 13, 15231 (2023). DOI: 10.1038/s41598-023-42104-2. Open Access.

Agnese Compagnone, An Matheeussen, Linda De Vooght & Paul Cos. Development and validation of a multiplex electrochemiluminescence immunoassay to evaluate dry eye disease in rat tear fluids. Scientific Reports. 13, 12203 (2023).DOI: 10.1038/s41598-023-39397-8. Open Access.

Camilla Scarpellini, Sophie Valembois, Kenneth Goossens, Mike Vadi, Caroline Lanthier, Greta Klejborowska, Pieter Van Der Veken, Hans De Winter, Mathieu J. M. Bertrand, and Koen Augustyns. From PERK to RIPK1: Design, synthesis and evaluation of novel potent and selective necroptosis inhibitors. Frontiers in Chemistry. Vol. 11, April 2023 DOI: 10.3389/fchem.2023.1160164. Open Access.

Alba Ramos-Llorca, Lisse Decraecker , Valérie M. Y. Cacheux, Irena Zeiburlina, Michelle De bruyn, Louise Battut, Carlos Moreno-Cinos, Davide Ceradini, Eric Espinosa, Gilles Dietrich, Maya Berg, Ingrid De Meester, Pieter Van Der Veken, Guy Boeckxstaens, Anne-Marie Lambeir, Alexandre Denadai-Souza and Koen Augustyns. Chemically diverse activity-based probes with unexpected inhibitory mechanisms targeting trypsin-like serine proteases. Frontiers in Chemistry, January 2023. DOI: 10.3389/fchem.2022.1089959. Open Access.

Anusha Balla, Bao Tran, Annika Valtari, Philipp Steven, Camilla Scarpellini, Koen Augustyns, Arto Urtti, Kati-Sisko Vellonen, and Marika Ruponen. A Novel Ferroptosis Inhibitor UAMC-3203, a Potential Treatment for Corneal Epithelial Wound. Pharmaceutics. 2023, 15(1), 118. DOI: 10.3390/pharmaceutics15010118. Open Access.

Camilla Scarpellini, Alba Ramos Llorca, Caroline Lanthier, Greta Klejborowska, and Koen Augustyns. The Potential Role of Regulated Cell Death in Dry Eye Diseases and Ocular Surface Dysfunction. International Journal of Molecular Sciences. 2023, 24(1), 731. DOI: 10.3390/ijms24010731. Open Access.


Davide Ceradini, Pavel Cacivkins, Alba Ramos-Llorca, and Kirill Shubin. Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease. Organic Process Research & Development. 2022. DOI: 10.1021/acs.oprd.2c00244Open Access.

Alba Ramos-Llorca, Camilla Scarpellini and Koen Augustyns. Proteases and Their Potential Role as Biomarkers and Drug Targets in Dry Eye Disease and Ocular Surface Dysfunction. International Journal of Molecular Sciences. 2022, 23(17), 9795. DOI: 10.3390/ijms23179795. Open Access.

Maha M. Abdallah, Martim Cardeira, Ana A. Matias, Maria Rosário Bronze and Naiara Fernández. Lactic Acid-Based Natural Deep Eutectic Solvents to Extract Bioactives from Marine By-Products. Molecules, 2022, Vol 27(14), 4356. DOI: 10.3390/molecules27144356Open Access.

Nikolaos Katsinas, Uta Gehlsen, Laura García-Posadas, Soraya Rodríguez-Rojo, Philipp Steven, María J. González-García and Amalia Enríquez-de-Salamanca. Olive Pomace Phenolic Compounds: From an Agro-Industrial By-Product to a Promising Ocular Surface Protection for Dry Eye Disease. Journal of Clinical Medicine, 2022, 11(16), 4703. DOI: 10.3390/jcm11164703. Open Access.

Luna Krstić, Pekka Jarho, Marika Ruponen, Arto Urtti, María J. González-García and Yolanda Diebold. Improved Ocular Delivery of Quercetin and Resveratrol: A Comparative Study Between Binary and Ternary Cyclodextrin ComplexesInt. Journal of Pharmaceutics. 2022, 122028. DOI: 10.1016/j.ijpharm.2022.122028Open Access.

Md Asif Khan Setu, Stefan Schmidt, Gwen Musial, Michael E. Stern, Philipp Steven. Segmentation and Evaluation of Corneal Nerves and Dendritic Cells From In Vivo Confocal Microscopy Images Using Deep LearningTrans. Vis. Sci. Tech. 2022;11(6):24. DOI:10.1167/tvst.11.6.24. Open Access.

Anusha Balla, Marika Ruponen, Annika Valtari, Elisa Toropainen, Marjo Tuomainen, Carmen Alvarez-Lorenzo, Eva M. del Amo, Arto Urtti and Kati-Sisko Vellonen. Understanding dexamethasone kinetics in the rabbit tear fluid: Drug release and clearance from solution, suspension and hydrogel formulations. European Journal of Pharmaceutics and Biopharmaceutics. March 2022; Vol.172, March 2022, 53-60. DOI: 10.1016/j.ejpb.2022.01.005. Open Access.

Maha M. Abdallah, Inês C. Leonardo, Luna Krstić, Amalia Enríquez-de-Salamanca, Yolanda Diebold, Maria J. González-García, Frédéric B. Gaspar, Ana A. Matias, Maria do Rosário Bronze and Naiara Fernández. Potential Ophthalmological Application of Extracts Obtained from Tuna Vitreous Humor Using Lactic Acid-Based Deep Eutectic SystemsFoods. 2022; 11(3):342. DOI: 10.3390/foods11030342Open Access.

Murat Akkurt Arslan, Ioannis Kolman, Cédric Pionneau, Solenne Chardonnet, Romain Magny, Christophe Baudouin, Françoise Brignole‐Baudouin and Karima Kessal. Proteomic Analysis of Tears and Conjunctival Cells Collected with Schirmer Strips Using timsTOF Pro: Preanalytical Considerations. Metabolites 2022, 12 (2). DOI: 10.3390/metabo12010002. Open Access.


Bao N. Tran, Martina Maass, Gwen Musial, Michael E. Stern, Uta Gehlsen and Philipp Steven. Topical application of cannabinoid-ligands ameliorates experimental dry-eye disease. The Ocular Surface. Vol. 23, 2021. DOI: 10.1016/j.jtos.2021.12.008Open Access.

Davide Ceradini and Kirill Shubin. One-pot synthesis of α-aminophosphonates by yttrium-catalyzed Birum–Oleksyszyn reaction. RSC Advance. (2021), 11, 39147–39152. DOI: 10.1039/d1ra07718jOpen Access.

Adrian Guerrero-Moreno, Hong Liang, Nathan Moreau, Jade Luzu, Ghislaine Rabut, Stéphane Melik Parsadaniantz, Antoine Labbé, Christophe Baudouin and Annabelle Réaux-Le Goazigo. Corneal Nerve Abnormalities in Painful Dry Eye Disease Patients. Biomedicines 2021, 9 (10), 1424. DOI: 10.3390/biomedicines9101424. Open Access.

Nikolaos Katsinas, Amalia Enríquez-de-Salamanca, Andreia Bento da Silva, Maria Rosário Bronze and Soraya Rodríguez-Rojo. Olive Pomace Phenolic Compounds Stability and Safety Evaluation: From Raw Material to Future Ophthalmic Applications. Molecules 2021, 26(19), 6002. DOI: 10.3390/molecules26196002. Open Access.

Nikolaos Katsinas, Soraya Rodríguez-Rojo and Amalia Enríquez-de-Salamanca. Olive Pomace Phenolic Compounds and Extracts Can Inhibit Inflammatory- and Oxidative-Related Diseases of Human Ocular Surface Epithelium. Antioxidants 2021, 10 (7), 1150. DOI: 10.3390/antiox10071150. Open Access.

Darine Fakih, Adrian Guerrero-Moreno, Christophe Baudouin, Annabelle Réaux-Le Goazigo & Stéphane Mélik Parsadaniantz. Capsazepine decreases corneal pain syndrome in severe dry eye disease. Journal of Neuroinflammation, V. 8, Article nr: 111 (2021). DOI: 10.1186/s12974-021-02162-7. Open Access.

Anusha Balla, Seppo Auriola, Angus C. Grey, Nicholas J. Demarais, Annika Valtari, Emma M. Heikkinen, Elisa Toropainen, Arto Urtti, Kati-Sisko Vellonen and Marika Ruponen. Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues. Pharmaceutics 2021, 13(5), 658. DOI: 10.3390/pharmaceutics13050658Open Access.

Nikolaos Katsinas, Andreia Bento da Silva, Amalia Enríquez-de-Salamanca, Naiara Fernández, Maria Rosário Bronze, and Soraya Rodríguez-Rojo. Pressurized Liquid Extraction Optimization from Supercritical Defatted Olive Pomace: A Green and Selective Phenolic Extraction Process. ACS Sustainable Chem. Eng. (2021). DOI: 10.1021/acssuschemeng.0c09426. Open Access.

Md Asif Khan Setu, Jens Horstmann, Stefan Schmidt, Michael E. Stern, Philipp Steven. Deep learning-based automatic meibomian gland segmentation and morphology assessment in infrared meibography. Scientific Reports, V.11, N. 7649 (2021). DOI: 10.1038/s41598-021-87314-8. Open Access.

Maha M. Abdallah, Simon Müller, Andrés González de Castilla, Pavel Gurikov, Ana A. Matias, Maria do Rosário Bronze, Naiara Fernández. Physicochemical Characterization and Simulation of the Solid–Liquid Equilibrium Phase Diagram of Terpene-Based Eutectic Solvent SystemsMolecules 2021, 26(6), 1801. DOI: 10.3390/molecules26061801. Open Access.

Luna Krstić, María J. González-García and Yolanda Diebold. Ocular Delivery of Polyphenols: Meeting the Unmet Needs. Molecules 2021, 26(2), 370. DOI: 10.3390/molecules26020370. Open Access.


Adrian Guerrero-Moreno, Christophe Baudouin, Stéphane Melik Parsadaniantz and Annabelle Réaux-Le Goazigo. Morphological and Functional Changes of Corneal Nerves and Their Contribution to Peripheral and Central Sensory Abnormalities. Frontiers in Cellular Neurosciences (2020). DOI: 10.3389/fncel.2020.610342. Open Access.

Cedric Joossen, Adrienn Baán, Carlos Moreno-Cinos, Jurgen Joossens, Nathalie Cools, Ellen Lanckacker, Lieve Moons, Kim Lemmens, Anne-Marie Lambeir, Erik Fransen, Peter Delputte, Guy Caljon, Pieter Van Der Veken, Louis Maes, Ingrid De Meester, Filip Kiekens, Koen Augustyns & Paul Cos. A novel serine protease inhibitor as potential treatment for dry eye syndrome and ocular inflammation. Scientific Reports, V.10, N.17268 (2020). DOI: 10.1038/s41598-020-74159-w. Open Access.

Fanny Joubert, Adrian Guerrero-Moreno, Darine Fakih, Elodie Reboussin, Claire Gaveriaux-Ruff, Maria Carmen Acosta, Juana Gallar, José Alain Sahel, Laurence Bodineai, Christophe Baudouin, William Rostène, Stéphane Mélik-Parsadaniantz, Annabelle Réaux-Le Goazigo. Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice. Biomedicine & Pharmacotherapy 132 (2020) 110794. DOI: 10.1016/j.biopha.2020.110794. Open Access.

Adrian Guerrero-Moreno, Darine Fakih, Stéphane Melik Parsadaniantz, Annabelle Réaux-Le Goazigo. How does chronic dry eye shape peripheral and central nociceptive systems? Neural Regeneration Research (2021) Feb; 16(2): 306-307. DOI: 10.4103/1673-5374.290895. Open Access.

Maha M. Abdallah, Naiara Fernandez, Ana A.Matias, Mariado Rosario Bronze. Hyaluronic acid and Chondroitin sulfate from marine and terrestrial sources: extraction and purification methods, Carbohydrate Polymers (2020), V.243. DOI:10.1016/j.carbpol.2020.116441. Open Access.