June 2023 - Hybrid Technical Meeting, Antwerp

  1. Long-term follow-up and impact studies for HPV vaccines
  2. Effective Communication for cervical cancer prevention and control
  3. Self-sampling as a screening and monitoring tool

Meeting Objectives

  • Review and discuss long-term follow-up and impact studies for HPV vaccines
    • Effectiveness and real-world impact
    • Data systems for assessing the impact of HPV vaccination programs
    • Challenges and prospects of long-term follow-up studies for HPV vaccination programs
  • Effective communication for cervical cancer prevention and control
  • Review and discuss HPV vaccine communication
    • Challenges and steps to improve uptake through communication
    • Effective communication strategies; health care system and community level
    • Provide real-life country or region examples of effective communication strategies for increased uptake or coverage
  • Cervical cancer screening
    • Discuss challenges associated with cervical cancer screening communication and ways to deal with loss-to-follow-up
  • Discuss self-sampling as a screening and monitoring tool
    • Discuss overview, limitations and challenges with self-sampling
    • Provide an overview of self-sampling studies implemented in various high and middle-income countries, the challenges associated and the way forward
    • Cost-effectiveness and implementation challenges
    • How to add self-sampling in organised cervical cancer screening programmes
    • Discuss mitigation strategies and ways to evaluate self-sampling as a screening tool

DAY 1 – Thursday, June 1, 2023

SESSION 1: WELCOME AND INTRODUCTION
Chair: Alex Vorsters (University of Antwerp)

  • Welcome and Introduction
    Alex Vorsters (University of Antwerp)
    (Video, Pdf)

SESSION 2: LONG-TERM FOLLOW-UP AND IMPACT STUDIES FOR HPV VACCINES
Chairs: Sharon Hanley (University of Aberdeen) & Suzanne Garland (University of Melbourne)

  • Use of real-world data for HPV vaccine trial follow-up in the Nordic region
    Susanne Krüger Kjaer (Danish Cancer Society Research Center)
    (Video, Pdf)

  • Real world impact data of HPV vaccine effectiveness in the UK
    Tim Palmer (Public Health Scotland)
    (Video, Pdf)

  • Assessing the impact of HPV vaccination programs in countries; ways to measure the real-word impact

  • How countries assess/measure the impact
  • Challenge of potential bias in reporting and interpreting results and how can we prevent a potential bias
  • Do we need standardization or how the assessment can be standardized?
  • How do LMICs report and measure the impact
  • How real-world impact data is measured in low-resource settings?
  • Secondary objective: show HPV vaccine impact in LMIC settings

Country examples (10 min per country example):

Colombia - Raúl Murillo (Hospital Universitario San Ignacio - Pontificia Universidad Javeriana) (Video, Pdf)

Zimbabwe - Grant Murewanhema (University of Zimbabwe/Ministry of Health and Child Care of Zimbabwe) - Online (Video, Pdf)

LMICs perspective  –  Iacopo Baussano (International Agency for Research on Cancer (IARC/WHO) (Video, Pdf)

Canada – Gina Ogilvie (University of British Columbia; BC Women's Hospital) (Pdf)

SESSION 3: EFFECTIVE COMMUNICATION FOR CERVICAL CANCER PREVENTION AND CONTROL

SESSION 3A: REVIEW AND DISCUSS HPV VACCINE COMMUNICATION
Chairs: Noel Brewer (University of North Carolina) & Paolo Bonanni (University of Florence)

  • HPV vaccine overall vaccine confidence worldwide
    Emilie Karafillakis (University of Antwerp, LSHTM)
    (Video, Pdf)

  • HPV vaccination communication strategies at different levels; healthcare system and community level
    Overview and challenges  -  2 country examples. One HIC and one LMIC example

Thailand – Suchada Jiamsiri (Ministry of Public Health Thailand) (Video, Pdf)

Tanzania – Fausta Michael (Ministry of Health Tanzania) - Online (Video, Pdf)

  • How to communicate transition to one dose strategy – Ireland experience
    Treasa Kelleher (Health Service Executive (HSE))
    (Video, Pdf)

  • UK single dose communication strategies at clinical and patient/parent level
    Cherstyn Hurley (UK Health Security Agency)
    (Video, Pdf)

  • HPV vaccine communication training for clinicians
    Noel Brewer (University of North Carolina)
    (Video, Pdf)

SESSION 3B: PANEL DISCUSSION - HPV VACCINE COMMUNICATION STRATEGIES –DISCUSS KEY CHALLENGES AND POSSIBLE SOLUTIONS 

  • Short overview - Steps to improve HPV vaccination uptake through communication post crisis in Denmark 
    Susanne Krüger Kjaer
  • Panellists: Siff Nelsen (WHO), Noel Brewer (University of North Carolina), Charles Nelson Kakaire (UNICEF), Aurélie De Waele (University of Antwerp)
    (Video)

SESSION 3C: HPV SCREENING COMMUNICATION
Chairs: Kate Cuschieri (NHS Lothian) & Maribel Almonte (WHO)

  • Framing cervical cancer screening messaging: challenges and gaps to address
    Sandra Van Dijk (Dutch National Institute for Public Health and the Environment)
    (Video, Pdf)

  • Framing cervical cancer screening messaging – gaps to address
    Kate Broun (Cancer Council Victoria)
    (Video, Pdf)

  • Interventions to increase uptake of cervical cancer screening in Sub-Saharan Africa
    Cervical cancer screening communication in low-resource settings

    Prajakta Adsul (University of New Mexico)
    (Video, Pdf)

  • Q&A (Video)

SESSION 3D: PANEL DISCUSSION - Cervical cancer screening communication–discuss key challenges and possible solutions  for loss-to-follow-up

  • Panellists: Kate Cuschieri (NHS Lothian), Armando Baena (IARC),  Yin Ling Woo (ROSE Foundation and University Malaya), David Hawkes (Australian Centre for the Prevention of Cervical Cancer)
    (Video)

DAY 2 – Friday, June 2 2023 

SESSION 4: SELF-SAMPLING AS A SCREENING TOOL AND MONITORING TOOL

SESSION 4A: SELF-SAMPLING AS A SCREENING TOOL
Chairs: Marc Arbyn (Sciensano) & Mario Poljak (University of Ljubljana)

  • Welcome
    Alex Vorsters (University of Antwerp)
    (Video, Pdf)

  • Worldwide use of HPV self-sampling for cervical cancer screening.
    Federica Inturrisi (US National Cancer Institute) (Pre-recorded/Online)
    (Video, Pdf)

  • Conclusions from the last update of meta-analyses on accuracy of HPV testing on self-samples & urine; potential to increase response rates.
    Marc Arbyn (Sciensano)
    (Video, Pdf)

  • Lessons learnt from VALHUDES studies

Belgian VALHUDES
Ardashel Latsuzbaia (Sciensano)
(Pdf)

European VALHUDES
Clementina Cocuzza (University of Milano-Bicocca)
(Video, Pdf)

  • IVDR – testing and self-sampling devices
    Maribel Almonte (WHO)
    (Video, Pdf)

  • Self-sampling; overview, challenges, limitations and management
    Matejka Rebolj (King's College London)
    (Video, Pdf)

  • Q&A (Video)

SESSION 4B: SELF-SAMPLING IMPLEMENTATION  IN LMICS
Chairs: Nelly Mugo (Kenya Medical Research Institute) & Gina Ogilvie (University of British Columbia)

  • Self-sampling implementation

Example from Australia
David Hawkes (Australian Centre for the Prevention of Cervical Cancer)

Example from the Netherlands
Kim Vos (Dutch National Institute for Public Health and the Environment)
(Video, Pdf)

Self-sampling experience from low and middle-income countries

  • The Implementation of a Primary HPV Self-Testing Cervical Screening Program in Malaysia through Program ROSE-Lessons Learnt and Moving Forward
    Yin Ling Woo (ROSE Foundation and University Malaya)
    (Video)

  • Example from Argentina: experience on self-sampling from the Jujuy demonstration project
    Silvina Arrossi (Centro de Estudios de Estado y Sociedad (CEDES) - Online
    (Video, Pdf)

  • Self-sampling in Uganda
    Gina Ogilvie on behalf of Carol Nakisige (Uganda Cancer Institute) 
    (Pdf)

  • Cervical cancer screening in older women and whether self-sampling could be an optimal screening modality for this older age group
    Mette Tranberg (University of Antwerp)
    (Video, Pdf)

  • Q&A (Video)

SESSION 5: BREAKOUT SESSION

  • Secretariat University of Antwerp (5 min)

SESSION 5: BREAKOUT GROUPS

  • Breakout Group 1:
    Chairs: Marc Steben & Eduardo Franco
  • Breakout Group 2:
    Chairs: Maribel Almonte & Yin Ling Woo

SESSION 6: CONCLUSION
Chairs: Eduardo Franco (McGill University) & Narendra Kumar Arora (The INCLEN Trust International)

  • Summary/Conclusions
  • Concluding Remarks 
    (Video)​