Research

Research group

Medical Biochemistry

Expertise

  • - Prolyl oligopeptidase in the central nervous system and prolyl oligopeptidase inhibitors: new therapeutic strategies in neurodegenerative disease and Carboxypeptidase M: substrates and interaction partners in health and disease (kidney, adipocytes). - Eiwit engineering en structuurgebaseerde ontwikkeling van geneesmiddelen: aspecten van enzymologie, eiwitchemie en moleculaire biologie. - Know-how in enzymology: research on catalytic mechanisms, kinetics and characterisation of enzyme inhibitors. Enzymes currently under investigation: prolyl oligopeptidase, carboxypeptidase M, dipeptidyl peptidase 4 (porphyromonas gingivalis). Other enzymes: proline specific peptidases, serine proteases of the coagulation and fibrinolysis systems, glucose isomerase, amylases and glucoamylases, glycolytic enzymes (such as triosephosphate isomerase, glyceraldehydephosphate dehydrogenase, glycerol kinase, hexokinase), thiolases, glutathionyl-spermidine synthase, peroxidases, prostaglandin H synthase (COX-1).-

Projects

You can find here all of the projects that are recorded in the research database of UAntwerp under the name of the academic staff member that acts as a promoter, copromoter or grant holder (a.o. FWO). It concerns only those research projects and mandates that were acquired after an external or internal competition.