Hans De Loof guest professor - associate professor

Research Hans De Loof

Research team

Expertise

Pharmaceutical care Pharmacotherapy Bioinformatics

iCAREdata, Improving Care and Research Electronic Data Trust Antwerp. 01/09/2023 - 31/08/2024

Abstract

iCAREdata is a state-of-the-art research database processing routine clinical data of out-of-hours (OOH) patient contacts at general practice cooperatives (GPCs) (huisartsenwachtposten), pharmacies and emergency departments (EDs). The database contains data starting from 2015 until to date. Dataflows are secured by encryption of the social security numbers of the patients by eHealth as a trusted third party (TTP), as well as the RIZIV numbers of the physicians. At no point in the flow, personal data can be matched to clinical data. In de final database, pseudonymised personal data enable the linkage of different patient contacts to the same person, offering the opportunity to describe patient trajectories in the OOH care services; e. g. Person X consults a general practitioner at the GPC on Saturday morning, goes to the pharmacie to collect the prescribed medicines in the afternoon of the same day and finally shows up during the night on Sunday morning at 2am at the emergency department. To realise this data flow and linkage, thorough knowledge about the use and implementation of eHealth services is crucial, besides an up-to-date experience in standardisation and classification systems currently used in medical research datasets. A large network of health care services and health care workers is being part of and has to be fully involved with this project. This is only realised by implementing full transparency about the content of the dataset, how the flow is set up, and for what kind of research the data are used and by who. Researchers as well as data-supplying stakeholders stress the importance of upscaling the datasets by expanding with all GPCs in Flanders (at this moment 38 out of 44 GPCs deliver data on a daily basis) as well as adding extra EDs and pharmacies. Researchers suggest to add routine data of daytime general practices. This is necessary in the long term to be able to follow the entire flow of patients. Also the link with patient contacts in telephone- or selftriage, callcentres for urgent medical care (HC112), and follow-up contacts in general practice or hospitals complete the patient trajectories at different sites. iCAREdata has strong links with newly developed tools in referral to and cooperation with welfare services. This is a unique link between medical care and wellbeing which is in scope to be developed during the upcoming years. Besides research opportunities, iCAREdata also offers the opportunity to add up to a data driven policy on the micro, meso and macro level of health care and welfare services organisation, which was a crucial issue during Covid-19 pandemic. In addition several scientific research topics make the database worthwhile to maintain: evaluation of drug prescriptions by physicians in several contexts (antibiotics, opioids, …), use of health care services, epidemiologic topics like surveillance of infectious diseases, gaps in the offer of health and welfare services, waiting lists…iCAREdata has an experienced team of computer scientists developing modular software based on Normalized Systems Theory (NST). These modular software structures enable the introduction of additional data providers in a fast and reliable way. Thanks to financial resources, iCAREdata will further develop, validate and finalize the link with the emergency services and pharmacies. This enables us to set up valuable use cases to acquire users and (paying) customers. The funding will also be used to further develop the public dashboard and the user dashboards.

Researcher(s)

Research team(s)

Project website

Project type(s)

  • Research Project

Community-wide assessment of the opioid burden through combined use of wastewater-based analytics and prescription drug monitoring data. 01/01/2019 - 31/10/2019

Abstract

In recent times, the use of opioids has escalated drastically and resulted in a crisis of epidemic proportions in North America. In Europe, the use of opioids has also increased, but in smaller proportions compared to North America. However, the extent to which opioids are (mis)used in Europe needs to be further explored. In this project, we will optimise and develop a highthroughput bioanalytical assay based on μSPE-LC-MS/MS capable of measuring a broad range of biomarkers of opioids use in the ng/L range in wastewater. We aim at obtaining near real-time, objective and complementary information on the use of opioids at high spatio-temporal resolution through a wastewater sampling campaign in different locations in Belgium. By generating highly relevant data on the consumption of opioids together with triangulation of this data with other existing datasets (e.g. Farmanet, Health Interview Survey,...), this project can aid in obtaining a better picture on the opioid use in Belgium which is of importance for policy makers in optimizing and evaluating prevention, treatment and harm-reduction strategies on the subject of pain management. Furthermore, by combining multiple datasets, information on the illegal use of opioids can be obtained. In a last step, the obtained data will be correlated with existing socioeconomicco-variates of the investigated communities to obtain a better insight on the relationship between socio-demographic features, and prevalence of use of opioids.

Researcher(s)

Research team(s)

Project type(s)

  • Research Project

The development of a quality control instrument for the evaluation of New Medicines Counselling (NMC). 15/05/2014 - 15/01/2015

Abstract

This project represents a formal research agreement between UA and on the other hand IFEB. UA provides IFEB research results mentioned in the title of the project under the conditions as stipulated in this contract.

Researcher(s)

Research team(s)

    Project type(s)

    • Research Project