Abstract
During the study of CD26/DPPIV in human leucocytes, it appeared that some of the X-Pro-releasing activity wasn't inhibited by DPPIV specific inhibitors. Preliminary experiments showed that at least some of the X-Pro-releasing activity was due to several other dipeptidylpeptidases.
Primarily human dipeptidyl peptidase II (DPPII) will be purified, followed by a biochemical and enzymological characterization (synthetical substrates and natural occuring peptides). Human leucocyte cellines and periferal blood mononuclear cells will be screened on the presence of DPPII. Following biological evaluation of new DPPII inhibitors (collaboration with the laboratory of farmaceutical chemistry, Prof. A. Haemers and Prof. K. Augustyns), the function of DPPII in human leucocytes will be studied.
Researcher(s)
Research team(s)
Project type(s)