5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein-Protein Interaction-Derived Functions

Source
Journal of medicinal chemistry - ISSN 0022-2623
Author(s)
    Henri T. Patsi, Tommi P. Kilpelainen, Mikael Jumppanen, Johanna Uhari-Vaananen, Pieter Van Wielendaele, Francesca De Lorenzo, Hengjing Cui, Samuli Auno, Janne Saharinen, Erin Seppala, Nina Sipari, Juha Savinainen, Ingrid De Meester, Anne-Marie Lambeir, Maija Lahtela-Kakkonen, Timo T. Myohanen, Erik A. A. Wallen

The chemokine-based peptide, CXCL9(74-103), inhibits angiogenesis by blocking heparan sulfate proteoglycan-mediated signaling of multiple endothelial growth factors

Source
Cancers - ISSN 2072-6694-13:20 (2021) p.
Author(s)
    Alexandra De Zutter, Helena Crijns, Nele Berghmans, Melissa Garcia-Caballero, Lotte Vanbrabant, Noemie Poertner, Vincent Vanheule, Paulien Verscheure, Mohammad Mairaj Siddiquei, Ahmed M. Abu El-Asrar, Peter Carmeliet, Pieter Van Wielendaele, Ingrid De Meester, Jo Van Damme, Paul Proost, Sofie Struyf

The history of anti-trypanosome vaccine development shows that highly immunogenic and exposed pathogen-derived antigens are not necessarily good target candidates : enolase and ISG75 as examples

Source
Pathogens - ISSN 2076-0817-10:8 (2021) p.
Author(s)