Late-stage diversification of rewired purine C-nucleosides reveals potent antitrypanosomatid agents with in vivo efficacy

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Journal of medicinal chemistry - ISSN 0022-2623-69:16 (2026) p. 19744-19758
Auteur(s)

A strategic discovery roadmap towards high-quality leads and drug development candidates for kinetoplastid diseases. Part 1: setting the stage

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The journal of antimicrobial chemotherapy - ISSN 0305-7453-81:5 (2026) p. 1-5
Auteur(s)
    Sarah Hendrickx, Kayhan Ilbeigi, Eli S.J. Thore, Michael G. Bertram, Estefania Calvo-Alvarez, Sener Cintesun, Ana Isabel Olias-Molero, Maria Jesus Corral, Marta Mateo-Barrientos, Jerome Estaquier, Sebastien Pomel, Jose Maria Alunda, Sheraz Gul, Katrien Van Bocxlaer, Frederic Frezard, Joana Tavares, Anabela Cordeiro Da Silva, Maria Paola Costi, Louis Maes, Guy Caljon

A strategic discovery roadmap towards high-quality leads and drug development candidates for kinetoplastid diseases. Part 3: from lead towards a drug development candidate

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The journal of antimicrobial chemotherapy - ISSN 0305-7453-81:6 (2026) p. 1-10
Auteur(s)
    Sarah Hendrickx, Kayhan Ilbeigi, Eli S.J. Thore, Michael G. Bertram, Estefania Calvo-Alvarez, Sener Cintesun, Ana Isabel Olias-Molero, Maria Jesus Corral, Marta Mateo-Barrientos, Jerome Estaquier, Sebastien Pomel, Jose Maria Alunda, Sheraz Gul, Katrien Van Bocxlaer, Frederic Frezard, Joana Tavares, Anabela Cordeiro Da Silva, Maria Paola Costi, Louis Maes, Guy Caljon

A strategic discovery roadmap towards high-quality leads and drug development candidates for kinetoplastid diseases. Part 2: from molecule to confirmed hit

Bron
The journal of antimicrobial chemotherapy - ISSN 0305-7453-81:4 (2026) p. 1-14
Auteur(s)
    Sarah Hendrickx, Kayhan Ilbeigi, Eli S.J. Thore, Michael G. Bertram, Estefania Calvo-Alvarez, Sener Cintesun, Ana Isabel Olias-Molero, Maria Jesus Corral, Marta Mateo-Barrientos, Jerome Estaquier, Sebastien Pomel, Jose Maria Alunda, Sheraz Gul, Katrien Van Bocxlaer, Frederic Frezard, Joana Tavares, Anabela Cordeiro Da Silva, Maria Paola Costi, Louis Maes, Guy Caljon

Discovery of a series of macrocycles as potent inhibitors of Leishmania infantum

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Journal of medicinal chemistry - ISSN 0022-2623-67:20 (2024) p. 18170-18193
Auteur(s)
    Federico Riu, Larissa Alena Ruppitsch, Duc Duy Vo, Richard S. Hong, Mohit Tyagi, An Matheeussen, Sarah Hendrickx, Vasanthanathan Poongavanam, Guy Caljon, Ahmad Y. Sheikh, Peter Sjo, Jan Kihlberg