Personalized SP against drug-evoked proarrhythmia

Host organisation: Maastricht University, Nederlands

Supervisor: Prof. Paul Volders


Safety pharmacology (SP) is a broad field of science encompassing investigations into multiple research topics, among which are safety assessments of the drugs affecting cardiovascular functionality. Even though a number of drugs such as antiarrhythmics can treat the disease, in ~3% of cases the existing arrhythmia can aggravate or a novel arrhythmia may develop. This life-threatening offside effect is proarrhythmia, and the project of Anna Savchenko from Maastricht University, ESR15 PhD candidate of INSPIRE, is focusing on revealing the genetic factors behind the proarrhythmia development. This study is aiming to elucidate the mechanisms of the offside effect by looking into the genetics, morphology and electrophysiology of the induced pluripotent stem cells (iPSCs) generated from the patients prone to drug-induced proarrhythmia.