Below you can find the current projects of the academic staff members that act as promoter, copromoter or grant holder (FWO/IWT). It concerns only those research projects and mandates that were acquired after an external or internal competition.

Improving diagnostics and care for childhood onset epilepsies and its common neurological co-morbidities in Tanzania (Joint-COE)

Abstract

Childhood onset epilepsies (COE) are important causes of childhood morbidity in Sub-Saharan Africa (SSA), and are frequently accompanied by neurodevelopmental disabilities such as intellectual disability (ID). The treatment gap in SSA amounts to 80%, and stigma associated with both epilepsy and ID further increase disease burden for children and caregivers. Genetic factors are assumed to play a major role in COE, but access to genetic testing is non-existing in Tanzania. In this project we will 1) strengthen the research capacity on COE in Tanzania by establishing a research group supporting resident neurologists and PhD students in the development of research protocols addressing COE in Tanzania, and 2) improve quality of life of children with epilepsy (CWE) in Tanzania by a) improving diagnosis and care for CWE, by strengthen-ing medical education and local implementation of genetic testing; b) reducing the treatment gap by educa-tion of caregivers of CWE, c) improving access and quality of community-based rehabilitation programs

Funding(s)

VLIR-UOS

Researcher(s)

Period

01/01/2020 - 31/12/2021

An international academic Family Medicine Network on interprofessional collaboration

Abstract

The aim of the project is to create an international platform for the participating universities to exchange case-driven experiences and proven solutions at two levels: 1. train FM/PHC professionals in the competencies of interprofessional team working in the participating countries by exchanging working experiences via an interactive web-based platform and 2. increase knowledge, skills and expertise about early recognition and self-management of type 2 diabetes mellitus (T2DM) ) through interprofessional learning at community health centres (CHCs) and private clinics in urban and rural areas.

Though the focus of the case-based experiences will be on T2DM early detection and self-management, the main purpose of this project will be on exchanging needs and experiences for working interprofessionally by the participating academic centres via a web-based platform. There will be a yearly live meeting and regular (bimonthly) webinars or digital meetings (zoom, skype, …) of the leading teams in the different countries, and monthly meetings of the national network of (urban, rural, remote,…) participating CHCs and private clinics within each country.

Funding(s)

Researcher(s)

  • Johan Wens
  • Minh Tam Nguyen

Period

01/01/2020 - 31/12/2021

EBOVAC3, Bringing a prophylactic Ebola vaccine to licensure

Summary

The EBOVAC3 project aims to assess, through clinical trials in children and adults in Africa, the safety and effectiveness of an Ebola vaccine regimen. As such it will help to improve the world’s preparedness to deal with an Ebola outbreak. The project focuses on the ‘prime-boost’ Ebola vaccine regimen (Ad26.ZEBOV and MVA-BN-Filo) prime-boost’ Ebola vaccine regimen, in which patients are first given a dose to prime the immune system, and then a boost dose which is intended to enhance the immune response over time. Building on work carried out under the EBOVAC1 and 2 projects, EBOVAC3 will run clinical trials in children in Sierra Leone, Guinea and the Democratic Republic of Congo. It will also follow up people who participated in earlier clinical trials in Sierra Leone, to assess the safety and efficacy of the vaccine in the longer term. Finally, the project aims to characterize the outbreak preparedness of Sierra Leone, Guinea and the Democratic Republic of Congo.

Funding

IMI: 8.541.213 €

Researchers:

UA coordinator: Pierre Van Damme

UA Co-coordintor: Jean-Pierre Van geertruyden

Period

01/06/2018 - 31/05/2023

more information on EBOVAC3 website and IMI project portal

Improved infectious diseases control in Peru through sustainable capacity building for bioinformatics and genome sequencing

Abstract

The Peruvian population is adversly affected by infectious diseases and current govermental efforts are not sufficient to reduce the burden. While bioinformatics and genomics are relatively new approaches in molecular epidemiology, they have already made important contributions to the health of patients and populations. Bioinformatics and genome sequencing capacity in Peru is still extremely limited. Public universities like UNSA in Arequipa and UNAP in Loreto could play a major role in regional and national level infectious disease control by providing further insights in the molecular epidemiology of the infectious diseases in Peru. We propose to develop sustainable capacity in bioinformatics and sequencing through the development of a academic network between 3 universities in Peru and 2 institutions in Belgium. We selected topics of local public health importance: malaria, tuberculosis and antibiotic resistance. For these diseases, next generation sequencing can significantly improve diagnostics, surveillance and control, thus contributing to better health of the population of Peru.

Funding(s)

VLIR-UOS

Researcher(s)

Promotor: Van Rie Annelies

Co-promotor: Delgado Ratto Chris

Period:

01/01/2019 -31/12/2021

Mapping and tracking drivers of antimicrobial resistance in Uganda

Abstract

In Uganda, 98.9% of rural children developed infections caused by microorganisms resistant to the antibiotic co-trimoxazole (Rutebemberwa 2015). Antibiotic-resistant bacteria increasingly challenges treatment of pneumonia and tuberculosis. Despite this, Uganda has no national policy to deal with antibiotic resistance, and very little public understanding of the consequences of inappropriate use of medicines. This project will contribute to the reduction of antimicrobial resistance in Uganda by increasing the research activity and capacity of the Faculty of Health Science at Busitema University, and providing evidenced-based solutions to reduce antimicrobial resistance. The project maps patterns of antibiotic resistance in Uganda, and the factors which drive them in four regions. Capacity building includes training Ugandan researchers in advanced quantitative and qualitative research methods, and publishing in ISI ranked journals. Dissemination includes training, workshops and training material for health professionals, and raising public awareness

Funding(s)

VLIR-UOS

Researcher(s)

Promotor: Van Royen Paul

Period

01/01/2018 -31/03/2020

Making cervix cancer screening accessible through self sampling in an intercultural context

Abstract

In this project we want to decrease the morbidity and mortality of cervical cancer in women in Ecuador by introducing screening based on self sampling. The project combines state-of-the-art screening practices with empowering women of different ethnic origins, taking into account cultural beliefs and involving traditional and local caregivers as intermediary health workers. To achieve this, we will develop an operational plan to optimize technical aspects of laboratory diagnosis, set up a logistic pathway, educate health workers and study the acceptability of the proposed strategies for the end-users. A strategy for follow up of screening results by means of telemedicine will be developed and introduced.

Funding(s)

VLIR-UOS

Researcher(s)

Promotor: Verhoeven Veronique

Co-promotor: Benoy Ina

Period

01/01/2020 -31/12/2021

Joint efforts for the Elimination of Malaria in the Peruvian Amazon

Abstract

Malaria burden severely affects the population living in the Peruvian Amazon, which is also affected by low-living conditions. Currently, the Peruvian government has launched the Malaria Elimination program in the Amazon and requires evidence-based research to improve its program. UNAP is the main university in the Peruvian Amazon and is looking to become a key role player on the development of the region by supporting this elimination initiative. The first steps of supporting UNAP becoming more active on research were initiated through a triangular collaboration between UNAP, UPCH and UAntwerp in 2016 (VLIR SI). Here by, we intend to continue and strengthen this collaboration by actively developing educational and research capacities on epidemiology, data analysis and population genetics at UNAP. Constant training through students/professors exchange, courses given by UAntwerp/UPCH professors at UNAP and joint research related to malaria elimination tools encircle the strategy proposed on this VLIR TEAM project.

Funding(s)

VLIR UOS, TEAM programme, 279.994€

Researcher(s)

Flemish promoter: Jean-Pierre Van geertruyden (University of Antwerp)
Local promoter: Dr. Dionicia Gamboa Vilela (Universidad Peruana Cayetano Heredia, Peru)

Period

01/01/2018 - 01/12/2021

Scaling-up Packages of Interventions for Cardiovascular disease prevention in selected sites in Europe and Sub-Saharan Africa: An implementation research (SPICES)

Abstract

The overall research objective of the SPICES project is to implement and evaluate a comprehensive CVD prevention and control program in five settings: a rural & semi-urban community in a low-income country (Uganda), middle income (South Africa) and vulnerable groups in three high-income countries (Belgium, France and United Kingdom) as well as to identify and compare the barriers and facilitators across study contexts. The project will be evaluated using a mix of qualitative and quantitative methods. At the beginning of the project, we will conduct baseline assessments including literature reviews, formative studies, household surveys (where feasible) and learn lessons from other projects to understand healthcare and lifestyle practices, barriers, and facilitators. A costeffectiveness and cost benefit analysis will be included. In addition, the teams will conduct site exchanges visits to learn from each other and organise policy dialogues to ensure sustainability and maximise impact of the interventions.

Funding(s)

Researcher(s)

  • Principal investigator: Bastiaens Hilde
  • Co-principal investigator: Anthierens Sibyl
  • Co-principal investigator: Van geertruyden Jean-Pierre
  • Co-principal investigator: Van Royen Paul

Research team(s)

Primary and interdisciplinary care Antwerp (ELIZA)

Period

01/01/2017 -31/12/2021

Website

www.spicesproject.eu

Multi-disciplinary approach to control onchocersiasis-associated epilepsy in the Mahenge area in Morogoro region, Tanzania.

Abstract

Despite the use of ivermectin (IVM) once annually for control of onchocerciasis (oncho) (= river blindness) in Mahenge Tanzania, the prevalence of oncho and epilepsy remains high. There is increasing evidence that epilepsy is a complication of oncho and that treatment of oncho can not only eliminate blindness but also reduce epilepsy. Our proposed project aims to: 1) strengthen the multi-disciplinary research capacity for the prevention of oncho and epilepsy in Tanzania. We will establish an oncho-associated epilepsy (OAE) research group to support a master and a PhD-level student in the development of research protocols addressing OAE in the Mahenge region; 2) reduce the prevalence of oncho and the incidence of epilepsy in the Mahenge area by: a) establishing a surveillance system for early diagnosis of epilepsy; b) strengthening and implementing an effective community distribution of IVM; 3) Implement evidence-based guidelines to treat OAE by training local health care workers; 4) introduce community advocacy on epilepsy, epilepsy-associated stigma and discrimination.

Funding(s)

VLIR UOS TEAM programme: 300.000€

Researcher(s)

Promotor: Colebunders Robert

Co-promotor: Weckhuysen Sarah

Period

01/01/2018 - 31/12/2021

Appui scientifique pour la realization du project interdisciplinaire/interuniversitaire en santé maternelle à Unikin et à Unilub

Abstract

This project represents a formal research agreement between UA and on the other hand VLIR. UA provides VLIR research results mentioned in the title of the project under the conditions as stipulated in this contract.

Funding(s)

VLIR

Researcher(s)

Principal investigator: Van geertruyden Jean-Pierre
Co-principal investigator: Maes Louis
Co-principal investigator: Jacquemyn Yves
Co-principal investigator: Bogers John-Paul

Period:

01/12/2014-30/11/2018

Research on European children and adults born preterm (RECAP)

Abstract

The project's overall aim is to improve the health, development and quality of life of children and adults born very preterm (VPT, < 32 weeks of gestation) or very low birth weight (VLBW, < 1500g) – approximately 50 000 births each year in Europe – by establishing an ICT platform to integrate, harmonise and exploit the wealth of data from 20 European cohorts of VPT/VLBW children and adults and their families constituted from the early 1980s to the present, together with data from national registries.

Funding(s)

Researcher(s)

  • Principal investigator: Lebeer Jo
  • Co-principal investigator: Merckx Joanna
  • Co-principal investigator: Van Rie Annelies

Research team(s)

Primary and interdisciplinary care Antwerp (ELIZA)

Period

01/01/2017 -30/04/2020

Website

https://recap-preterm.eu/

Development of a Centre for Whole Genome Sequencing studies of Mycobacterium.

Abstract

Tuberculosis (TB) is a global problem, with > 9 million cases annually and rising numbers of multi-drug resistant TB (MDR-TB). In the 1990's, IS6110 DNA fingerprinting revolutionized the study of Mycobacterium tuberculosis (MTB). Using this technique, I performed groundbreaking studies that proved exogenous reinfection, challenged the dogma that most TB cases are due to re-activation of latent infection, opposed the belief that most MDR-TB is acquired, and demonstrated mixed infection (NEJM 1999, JID 1999, Lancet 2000, AJCCRM 2005). The recent development of high-throughput, relatively low-cost whole genome sequencing (WGS) raises again the promise of significant gains in molecular epidemiology of MTB. Arriving at new paradigms however demands that inferences of WGS data on phylogeny, transmissibility, virulence and resistance are contextualized and integrated with clinical and demographic meta-data in large-scale studies to test the hypotheses generated by small-scale studies on isolates collected in low TB burden countries. As a clinical and molecular epidemiologist, I propose to establish and direct a multidisciplinary Centre for WGS studies of MTB at the University of Antwerp. The Centre will embed itself in the molecular microbiology laboratory of Prof Herman Goossens, who has substantial expertise in WGS research of pathogens other than MTB. The Centre will work in close collaboration with Prof Robin Warren of the South African Centre of Excellence for Biomedical Tuberculosis Research (CEBTR), Stellenbosch University. Access to the ~50,000 MTB strains in the CEBTR biobank will provide a unique opportunity for the Centre to perform molecular epidemiological MTB studies that address ground-breaking basic science and molecular epidemiological questions. To maximize the public health gains of WGS, we will focus on studies of MTB transmission dynamics in a high TB burden setting, the role of epistatis in emergence of drug resistance, MTB adaptation to drug pressure, and within-host MTB diversity.

Funding(s)

FWO

Researcher(s)

Principal investigator: Van Rie Annelies

Period

01/10/2016 - 30/09/2021

Improved infectious diseases research and surveillance in Ethiopia through capacity building in bioinformatics and sequencing.

Abstract

Even though bioinformatics and genomics are relatively new biomedical disciplines, they have already made important contributions to the health of patients and populations. Bioinformatics and genome sequencing ca-pacity in Ethiopia is however extremely limited. African scientists are well positioned to play an important role in sequencing-based surveillance and research because the cost of sequencing technologies has dropped dra-matically, internet connectivity is constantly improving, and bioinformatics software tools are often freely availa-ble. We propose to develop sustainable capacity in bioinformatics and sequencing surveillance and research through an academic collaboration between Ethiopia, South Africa and Belgium. We selected topics of local public health importance: hospital acquired infections, vector borne diseases and tuberculosis. For these dis-eases, sequencing can significantly improve diagnostics, surveillance and control, thus contributing to better health of the population of Ethiopia.

Funding(s)

VLIR UOS Joint project, 150.000€

Researcher(s)

Promotor: Van Rie Annelies

Period

1/01/2018 - 31/12/2020

Epidemiology and social medicine (ESOC)

Set up of HPV reference centre and establishment of HPV research network within the African.

Abstract

HPV is the main, almost unique cause of cervix carcinoma in adult women. Unfortunately, currently, many African countries lack comprehensive data on the circulating HPV types and Africa may harbor a variety of unexplored circulating HPV types which are uniquely distributed in various cancers and benign lesions.
This NSS initiative will establish a HPV research network between several VLIR partners of whom some are already conducting HPV and/or cervix carcinoma research with own VLIR-UOS funding.

Funding(s)

VLIR-UOS

Researcher(s)

Principal investigator: Bogers John-Paul, Jean-Pierre Van geertruyden

Period

13/12/2013-31/05/2015

Website

www.wakahpvafrica.com

Partner programme (2010-2019) for Institutional University Cooperation between University of Limpopo, Republic of South Africa and the Flemish Universities.

Abstract

This project represents a formal research agreement between UA and on the other hand VLIR. UA provides VLIR research results mentioned in the title of the project under the conditions as stipulated in this contract.

The overall program focus is on “Human Wellness in the context of Global Change - finding solutions for rural Africa”, with 6 project focus areas:

  • Data management, statistical analysis and GIS
  • Prevention, control and integrated management of chronic diseases
  • Multiple literacies
  • Laboratory science and public health management of sexually transmitted infections
  • The impact of land-use on functions of the Limpopo and Oliphant’s river systems
  • Food security

These focus area entails research, teaching and community outreach activities. The overall objectives are to strengthen capacity of staff and students, research, and community engagement through integrated, multi-disciplinary research projects, ultimately aimed at rural community beneficiation.

Funding source:

VLIR-UOS

Funding:

+/- € 2,8 million

Researcher(s)

Principal investigator: Colebunders Robert, Jean-Pierre Van geertruyden

Funding period

01/01/2010-31/12/2019

Partners:

University of Limpopo (Profs K. Ayisi, M. Lesaoana, T. Sodi, T, Mahlapahlapana, Nchabeleng, A. Jooste, and J. Ng’ambi ),
UHasselt (Prof C. Faes),
Uantwerpen (Profs H. Bastiaens, J.P. Bogers, and L. Bervoets),
UGent (Prof M. Valcke),
Vrije Universiteit Brussel (Prof E. Van Driessche)
and over 40 other Flemish senior researchers

Website

http://www.vlir-iuclimpopo.com

The cognitive, psychomotorical and physical impact of malaria and other (infectious) diseases in school aged children

Abstract

Malaria and anaemia are major causes of morbidity and mortality in children. Declining malaria has changed the shifted the burden of malaria to school children. Chemoprevention strategies using sulfadoxine-pyrimethamine (SP) was shown to prevent the incidence of malaria and anaemia in infants and school children in an area with low SP resistance. However, it is not clear whether this observation can be generalised to areas with high SP resistance. High levels of SP resistance are recorded in Eastern and Southern Africa and therefore alternative options needs evaluation as SP resistance continue to spread in the continent. There is, therefore, an urgent need to identify alternative drugs that could be used for IPTsc instead of SP. In addition , soil transmitted helminths co-morbidities continues to be unacceptably high in school-aged children, thus strategies for interrupting transmission needs to be optimized . We propose a randomized clinical trial to comparing the efficacy and safety of IPTc using dihydroartemisinin plus piperaquine and SP with piperaquine versus SP in high SP-resistance area.

Funding(s)

VLIR UOS, TEAM programme, 300000€

Researcher(s)

Flemish promoter: Jean-Pierre Van geertruyden (University of Antwerp)
Local promoter: John LUsingu (National Institute for Medical Research)

Period

01/01/2017-01/12/2020

The control of intestinal worms and schistosomiasis in Burundi.

Abstract

The final aim of this research will be to provide new strategies and tools to detect schistosomiasis in a context in which the estimated current prevalence is below 10%. This project will provide a proof of principle of new possible approaches in alternative to blanket mass drug administration in view of the elimination of schistosomiasis and possibly other worm infections in Burundi.

Funding(s)

INT. INST.

Researcher(s)

Principal investigator: Van geertruyden Jean-Pierre

Periode

01/02/2014-01/12/2017

The relevance of the family in adressing food, health and environment insecurity.

Abstract

This project represents a formal research agreement between UA and on the other hand VLIR. UA provides VLIR research results mentioned in the title of the project under the conditions as stipulated in this contract.

Funding(s)

FED. INST.

Researcher(s)

Principal investigator: Van geertruyden Jean-Pierre

Period

01/04/2013-31/03/2019

Website

www.vlirugandaresearchplatform.com/

Innovative approaches to integrated primary care for marginalized, at-risk populations in informal settlements in urban South Africa

Description:

Sub-studies of this large project aim to identify (1) the optimal sampling methods and diagnostic assays to diagnose pediatric tuberculosis at primary care level and (2) TB care and treatment default tracing and active household TB case finding by community health workers.

Funding source:

United States Agency for International Development (USAID)

Total ammount of funding:

+/- € 12 million

Funding period:

2012 - 2017

Role of EfGHI:

Prof Annelies Van Rie is co-Principal Investigator

Partners:

Witkoppen Health and Welfare Centre, Johannesburg, South Africa (Dr Jean Bassett),
University of John Hopkins, Baltimore, USA (Prof Colleen Hanrahan)

Optimal dosing of 1st line antituberculosis and antiretroviral drugs in children- a pharmacokinetic study

Description:

This study will evaluate the 2010 WHO dosing recommendations for first line antituberculosis drugs in HIV-infected and uninfected children in South Africa and Malawi.

Funding source:

US National Institute of Health

Total ammount of funding:

+/- € 1.9 million

Funding period:

2011 - 2016

Role of EfGHI:

Prof Annelies Van Rie is a co-investigator

Partner:

University of Cape Town (Helen McIlleron, PI)

Combining Xpert and GIS to identify areas with high TB transmission

Description:

The research investigates the use of the Xpert MTB/RIF assay cycle threshold as a measure of MTB infectious pressure and lay the ground work for innovative advanced surveillance of TB transmission as well as the development of novel, targeted interventions to help break the cycle of transmission of drug sensitive and drug resistant TB

Funding source:

US National Institute of Health

Total amount of funding:

+/- € 317,000

Funding period:

2015-2017

Role of EfGHI:

Prof Annelies Van Rie is co-Principal Investigator (South Africa PI Scott)

Partner:

University of the Witwatersrand, Johannesburg, South Africa

South Sudan Nodding Syndrome Study. A study into the epidemiology, aetiology and outcome of nodding syndrome in South Sudan

Abstract:

It is proposed to conduct an integrate program combining a case- control design with a detailed descriptive study using a phased approach. In the first phase a pathogen discovery programme will be applied on a limited number of NS patients and a group of controls using state of the art next generation sequencing and microarray-based methods on samples obtained from children and black flies. The focus of the second phase of the study will depend, in part, on the outcome of first phase: If a possible pathogen is identified the focus in the second phase will be on further identification of this pathogen. If no pathogen is identified, a detailed descriptive aetiology studies will be started using a case- control design and investigating all possible aetiologies previously indicated. Irrespective of the outcome of phase 1, in the second phase a surveillance study will also be started of all NS cases in the four most affected counties of South Sudan, next to a long term follow up of a selected group of NS cases and controls. This 3 years program will be conducted in close collaboration with South Sudanese, Dutch and Belgium NS and paediatric research experts and will be built on existing NS research and support activities already in place in South Sudan. Expected outcome: There is a significant chance that the true aetiology and the risk factors for NS will be identified and that the NS epidemiology in South Sudan will be clarified with respect to incidence, prevalence and disease progression. In addition, the study will create a platform for treatment intervention studies and will inform local health authorities how to improve their disease management and prevention strategies.

Funding:

Amsterdam Institute for Global Health and Development (AIGHD)
Academic Medical Centre
University of Amsterdam

Co-Applicant:

Prof. Robert Colebunders

Period:

01/01/2015 - 31/12/2017

Réduire d'épilepsie des rivières en République Démocratique du Congo

Abstract

L’épilepsie des rivières observé dans des régions hyperendémique pour l’onchocercose  est un syndrome neurologique inexpliqué. Notre hypothèse est que cette forme d’épilepsie, qui inclus le syndrome de hochement de tête (Nodding Syndrome), est causé par un pathogène encore inconnu transmis par les Simulii (l’insecte qui également transmet la cécité des rivières). Avec  notre projet nous voulons tester cette hypothèse et évaluer dans la Province Orientale de la RDC, des interventions qui puissent réduire l’incidence de cette épilepsie.

Funding

VLIR-UOS (South Initiative)

Researcher(s)

Principal investigator: Colebunders Robert
Investigator: Jean-Pierre Van geertruyden

Partner:

Prof. B. AgassaUniversité de Kisangani, RD Congo

Joint project to strengthen research skills on molecular epidemiology and to uncover malaria transmission features relevant for its control in the Peruvian Amazon

Abstract

The present project seeks to fulfil the academic capabilities of UNAP by improving quality of research and education. The project relies in the formation of a triangular structure of academic and educational collaboration between the UNAP (public university, academically weak but with high potential as key player in the development of Amazon population), UPCH (well-stablished university will lead UNAP on the project) and UA (supporting the capacity building). The VLIR Sl project will strengthen the academic and operational capacities on molecular epidemiology through active coaching and training in epidemiology, biostatistics and population genetics. From the start of the project UA will provide support to the Peruvian partners on population genetics analysis for which a computer cluster and the respective training will be provided in Peru.

Funding(s)

VLIR-UOS, South Initiative

Researcher(s)

Principal investigator: Jean-Pierre Van geertruyden and Christopher Delgado Ratto

Partners:

Universidad Peruana Cayetano Heredia
Universidad Nacional de la Amazonía Peruana

Period

13/03/16 - 31/12/2017

An investigation into the geographical distribution, host species, burden of disease and optimal diagnosis and treatment of Emmonsia hoerikwaggiana infections.

Abstract

Our group has discovered a new species of dimorphic fungal infection in South Africa. This is the first new species of dimorphic fungus that infects humans to be found for over 50 years. We have named the organism Emmonsia hoerikwaggiana. It causes severe disease and, if untreated, death in persons with poor immune function such as those infected with HIV. We know very little about this fungus. We will investigate its ecological niches, its geographical range, which organisms it usually infects, what the prevalence is of human infections and how these infections manifest. In addition we want to do further investigations into the risk factors for human infection and the optimal diagnostic and therapeutic strategies.

Funding(s)

FWO

Researcher(s)

Principal investigator: Colebunders Robert

Period

01/01/2014-31/12/2017

#emmonsia #southafrica

Reinforcement d'une unité de recherche clinique à l'UNIKIN, en République Démocratique du Congo.

Abstract

This project represents a formal research agreement between UA and on the other hand VLIR. UA provides VLIR research results mentioned in the title of the project under the conditions as stipulated in this contract.

Funding(s)

FED. INST.

Researcher(s)

Principal investigator: Van geertruyden Jean-Pierre

Period

01/06/2012-30/05/2015

Joining efforts to detect and control Plasmodium falciparum resistance in East and Central Africa.

Abstract

This project represents a formal research agreement between UA and on the other hand VLIR. UA provides VLIR research results mentioned in the title of the project under the conditions as stipulated in this contract.

Funding(s)

VLIR

Researcher(s)

Principal investigator: Van geertruyden Jean-Pierre

Period

01/07/2014-30/06/2016

Improving maternal and child health in the South Ethiopian Rift Valley

Flemish project leader: Jean-Pierre Van geertuyden (University of Antwerp)
Local project leader: Wanzahun Godana

Project within the Institutional cooperation with Arba Minch University (AMU), Ethiopia

Flemish programme coordinator: Roel Merckx (KU Leuven)
Local programme coordinator: Guchie Gulie Sulla

Phase I started on 1 January 2017.

More information on the VLIR UOS website
 

Création d'une unité interdépartementale de recherche clinique à la Faculté de médecine de l'Université de Lubumbashi (UNILU)

Abstract

La RD Congo et l' l'Université de Lubumbashi (UNILU) souffrent d'une grave carence du personnel compétent en recherche scientifique clinique de qualité internationale et en relève académique; surtout en pathologies infectieuses. Ce projet initial vise à créer une unité de recherche clinique à la Faculté de médecine de l'UNILU. Pour s'y faire, ce projet permettra la formation du personnel académique dans la conduite des recherches cliniques mais aussi en épidémiologie et statistiques. La formation du personnel scientifique se concrétisera par la réalisation de 7 projets de recherches sélectionnés de manière compétitive avec un sup-port adéquat de laboratoire. Les récipiendaires bénéficieront des cours ad hoc et d'un encadrement des professeurs de l'UA, de l'UNIKIN et de l'UNILU afin de pouvoir continuer avec leur projet de recherche jusqu'au niveau doctoral.

Funding(s)

VLIR-UOS

Researcher(s)

Principal investigator: Jean-Pierre Van geertruyden

Partner:

Abdon Mukalay, Université de Lubumbashi

Period

13/03/16 - 31/12/2017

Nodding Syndrome: a trans-disciplinary approach to identify the cause and decrease the incidence of river epilepsy (NSETHIO)

Abstract:

Nodding syndrome (NS) is a neurological, incurable syndrome, currently affecting mainly children between 5 and 15 years of age in South Sudan, Uganda and Tanzania. Since 1950, when NS was first described, its cause has remained a mystery. NS is characterized by head-nodding (an atonic form of epilepsy), often followed by clonic - tonic seizures, developmental retardation and faltering growth. In the affected regions, NS is a major public health problem associated with severe socio-economic consequences. After exploratory missions to South Sudan, Uganda and the Democratic Republic of the Congo (DRC), we gathered epidemiological evidence that supports the hypothesis that NS is a disease caused by a pathogen transmitted by blackflies, the vectors that transmit the parasitic worm that causes onchocerciasis. We hypothesise that the same disease is also endemic in other onchocerciasis hyper-endemic regions e.g. in the Mbam valley, Cameroon and the Orientale Province, DRC (where it is referred to as “river epilepsy”). In this project we aim to investigate our hypotheses in South Sudan, Uganda, Tanzania, Cameroon and the DRC with a trans-disciplinary approach including clinical-epidemiological, post-mortem, eco-entomological, and metagenomic studies. We will study the effect of vector control methods and ivermectin distribution on the incidence of river epilepsy. So far a multi-country study on NS was never done and nearly all previous studies were cross-sectional, carried out during short country visits. With this long term research plan we hope to finally discover the cause of NS and detect effective control strategies to decrease the incidence of epilepsy in onchocerciasis endemic areas.

Funding

EU, Horizon 2020

Budget

€ 2417000

Investigator:

Prof. Robert Colebunders

Partners:

Universitaetsklinikum Bonn, Germany

San Diego State University Foundation, United States

Period

1/10/2015 - 30/09/2020

Website

Infectious Diseases

Flemish project leader: Annelies Van Rie (University of Antwerp)
Local project leader: Delenasaw Yewhalaw

project within the Network cooperation in Ethiopia

Coordinating university: Jimma University (JU)

Other partner universities:

Ambo University
Hawassa University
Debre Zeit College of Veterinary Medicine and Agriculture

Flemish programme coordinator: Luc Duchateau (Ghent University)
Local programme coordinator: Kora Tushune (Jimma University)

 

Phase 1 started on 1 January 2017.

More information on the VLIR UOS website

Phase II partner program (2014-2017) for the Institutional University Cooperation between the University of Burundi and the Flemish universities

Description:

Strengthening the quality of the training and increase human resources in the priority sectors as basic sciences and pharmacy, rural development, medicine,  and human rights, Informatics & computer Technology

  • Support to  research in basic sciences and pharmacy
  • Rural development and food security in the provinces of Kayanza and Ngozi
  • New Technologies of Information and Communication
  • Contribution to improvement of training, medical research in community health care
  • Support to capacity building for teaching and research in the faculty of law 

Funding source:

Flemish Interuniversity Research (VLIR-UOS)

Total amount of funding:

+/- € 3.0 million (* 0.6 M for Community Health project)

Funding period:

2012-2021

Role of EfGHI:

Prof Van geertruyden is co-investigator (Project leader of Community Health project) (PI: S. Vandeginste)

Partner(s)*:

University of Burundi (Prof J. Ndikubagenzi),
UAntwerpen (Profs. H. Bastiaens, J.P. Bogers, Y. Jaquemyn),
UGent (Profs D. Vanden Broeck, P. Kolsteren)
*limited to Community Health project,

European and South African HIV co-infection research consortium (ESAHIV coinfRes).

Abstract

The overall aim of the proposed staff exchange program is to establish a long lasting collaboration between South African and European research teams involved in HIV coinfection research. This effort ultimately should lead to new ways to improve the
care/treatment for patients with HIV co-infections and to decrease the high mortality among persons with HIV infection in Africa.

Funding(s)

EU-KADER

Researcher(s)

Principal investigator: Van geertruyden Jean-Pierre

Period

01/11/2011-31/10/2015

Bridging the gap between clinical epidemiological research and the community by strengthening community health research.

Abstract

Despite evidence based policies, drug availability for most common diseases varies dramatically from place to place. Furthermore, health professionals have acquired limited competences to manage an operational district after graduation. Through qualitative and quantitative research projects we will assess various human behavioural aspects which may affect directly or indirectly the genesis and spread of drug resistance. Equally, we will assess the quality and quantity of the medicines availabele and assess the level of drug resistance of circulating pathogens.

Funding(s)

FED. INST.

Researcher(s)

Principal investigator: Van geertruyden Jean-Pierre

Period

01/07/2013-30/06/2018