This page lists some of the expertise of our research members. Contents are automatically generated from the central databases of the University of Antwerp. Contact the individual staff members for more info.

Baets Jonathan

Neurogenetics, molecular genetics, neuropathology, clinical neurology, clinical neurophysiology

Technique

molecular genetics, histopathology, clinical neurophysiology

Users

neurologists, neuroscientists, geneticists

Keywords

Genetic disease, Pathomechanism, Neuropathology, Neuro muscular diseases, Hereditary neuropathies

Boudewyns An

Research on congenital hearing loss in collaboration with the department of Medical Genetics of the University of Antwerp. Research on airway problems and sleep-related breathing disorders in children with Down syndrome in collaboration with the department of Pediatrics at the Antwerp University Hospital. Research on pediatric sleep disordered breathing in collaboration with the department of pediatrics of the Antwerp University Hospital and international collaboration with the European Respiratory Society (ERS) Pediatric Sleep Group.

Technique

sleep endoscopy and direct laryngoscopy polysomnography

Users

pediatricians, ENT surgeons

Keywords

Hereditary, Airway

Braem Marc

Dynamic / cyclic loading of mini-samples at low loads and evaluation of dental damage.

Technique

- Flexural fatigue - Micro-shear fatigue - Servo-hydraulic puls fatigue machine for heavy loads

Users

- ENT: study of small hearing bones - Orthopedics: study of fixation material

Keywords

Forensics, Composites, Dental materials, Fatigue, Dentistry, Adhesive agent

Ceulemans Berten

Epilepsy in children: clinical, genetic and treatment aspects. Fenfluramine as new anticonvulsive treatment. Dravet syndrome: clinical aspects.

Technique

Clinical. We do not do lab examinations.

Users

Expertise in all aspecyts from epilepsies in children.

Keywords

Child development, Epileptic encephalopathies, Epilepsy gene, Epilepsy, Genetics, Anticonvulsants

Cras Patrick

Neuropathology of human and animal nervous system, immunohistochemistry of nervous system specific proteins, immunodiagnosis of cerebrospinal fluid, enzyme linked immunoassay protein TAU and amyloid-beta, immunoblotting of 14-3-3.

Technique

- Light- and electronenmicroscopy - Histochemistry - Immunohistochemistry - Ultramicrotomy - Immunoblotting - Enzyme linked immunoassay - Chromatographic techniques

Users

- Neuroscientists - Biomedical scientists - Biologists - Veterinarians - Medical doctors

Keywords

Parkinsons disease, Dementia, Prion disease, Electron microscopy, Epidemiology, Immunocytochemistry, Neurology, Neuropathology, Enzymes

Crosiers David

Clinical neurology, neurogenetics, molecular genetics, movement disorders, neurodegenerative brain diseases, Parkinson's disease, dystonia, tremor

Technique

clinical research, molecular genetics

Users

Physicians, paramedical professions, neurologists, neuroscientists, geneticists

Keywords

Genotype-phenotype correlation, Parkinsons disease, Neurology, Genetics

De Groot Veva

Clinical glaucoma studies. Research concerning optic disc, and influence CSV on glaucoma

Technique

OCT visual field fundus exam visual acuity eye pressure

Users

colleagues companies producing glaucoma medication

Keywords

Genetic disease

Koppen Carina

The Antwerp Research Group for Ocular Science (ARGOS) focuses on translational research of the anterior segment of the eye using techniques of regenerative medicine and tissue engineering. We conduct projects from bench to bed side by a unique combination of clinicians and basic researchers. Our focus is on the ocular surface with research lines on regeneration of the epithelium, stroma and endothelium of the cornea and conjunctiva. The approach is multidisciplinary thanks to local, national and international network connections. Our expertise includes the development and optimization of primary cell isolation and cell culture protocols without using animal products, designing biological and synthetic scaffolds, and testing their biocompatibility. Through our partnerships, we have the opportunity to work with 3D printing, micro-contact printing and with different types of hydrogels. Specifically, we successfully completed a phase I / II study in which limbal corneal epithelial stem cells were expanded ex vivo on an amniotic membrane for transplantation. We are further building on the acquired expertise: we are specifically focused on the development of a conjunctival substitute and smart scaffolds for endothelial transplantation. The latest project concerns cornea-on-chip in which a three-dimensional dynamic tissue environment is created to better model human physiology in a lab environment. The Visual Optics Lab Antwerp (VOLANTIS) studies the optical aspects of the human eye, with special attention to normal and pathological refractive development. To this end, we develop statistical and biomechanical models that innovatively describe normal eye growth, as well as the inter-individual differences that exist in the general population to better understand myopia and other refractive disorders. The unique collaboration between clinicians, optometrists, mathematicians, and physicists has already led to fundamental advances in the early detection of keratoconus and predicting the future course of the disease, allowing individualized treatment to be offered to the patient. Another line of research focuses on how glare from bright lights can affect daily functioning in tasks such as driving a vehicle safely. Finally, research is also being carried out on pediatric cataracts to gain more pathophysiological insight into this developmental disorder and the results of the surgical treatment.

Technique

Argos: cel culture, immunohisto-/cytochemistry, PCR and high throughput live cell imaging. Volantis: prospective and retrospective data collection in the clinic, statistical models and analysis, ray tracing, finite element modeling, machine learning.

Users

Clinicians and researchers involved in ophthalmology, at home and abroad. Specifically for Argos: researchers interested in tissue engineering and regenerative medicine.

Keywords

Corneal regeneration, Optical eye modelling

Maas Andrew

Large database with individual patient data of traumatic brain injuries (IMPACT database).

Technique

Access to the data can be provided following submission of research questions and establishment of an agreement on data use.

Users

Researchers in the field of traumatic brain injury.

Keywords

Prognosis, Brain trauma, Neurosurgery, Clinical study

Rozema Jos

In the coming years the VOLANTIS research group, plans to conduct several studies related to visual optics and ocular biomechanics. Overall, these studies may be grouped into three topics. The first is refractive development and eye modelling, which studies how the eye grows and how this can be described as a mathematical model. Such models will look at e.g. how during eye growth the different components of ocular biometry interact with each other to first bring the eye in focus ('emmetropia') and then maintain this condition as the eye continues to grow. Other studies look at what happens if such a balance is disrupted or how it is accomplished in pathological eyes (e.g. premature infants or infants operated for cataract). Within the European OBERON project, we will also develop a new type of model that combines the biomechanics of the eye with its optical function as a platform for testing new treatments in virtual clinical trials. This 'opto-biomechanical' model will need close interactions with our European partners. The next study topic is keratoconus, a disease that gradually deforms the cornea, leading to a considerable loss in visual quality. Early detection of the disease and its possible progression is very important in its management as it allows the patients to preserve a higher visual quality through timely treatment. To this end, we are working on machine learning systems that can tell ophthalmologists whether an eye has keratoconus and, if so, if it is in a progressive state. Another project looks at improving the popular 'crosslinking' treatment that increases corneal elasticity and stops the progression. To do this, we need to develop corneal elasticity maps that can inform ophthalmologists what areas of the cornea need treatment. Although the current methods to develop such maps are very computationally intensive, we will use new methods that have not yet been tried to speed up this process from several hours to minutes, making it clinically useful. Finally, we will study straylight and dark adaptation, which refers to being blinded by bright lights ('glare') and the time needed to recover afterwards. These phenomena can play a major role in traffic safety as drivers may be blinded by the headlights of oncoming cars. Since it is not yet understood at what level of glare the safety risks for safe driving become too high, we will organize a study to test the effect of a bright light source on performance in a driving simulator in a darkened room. The outcomes of these experiments will later be formulated as advice to legislative authorities to improve traffic safety.

Technique

Clinical eye measurements Eye modelling

Users

Researchers, doctors, journalists

Keywords

Visual optics, Myopia, Eye modelling

Tassignon Marie-Jose

Lens and lens capsule Biometry Epidemiology of refraction and biometry Physiological optics Keratoconus IOL exchange Glaucoma Densitometry Quality of vision Artificial iris Floaters Macular edema Straylight Thyroid associated ophthalmopathy and VEP Genetic characteristics of the lens capsule Genetic characteristics of keratoconus patients Statistical eye models (adults, children) Stem cell transplantation Biocornea

Technique

- Aberrometer - OCT - Biometer - New Generation Sequencing for RNA/DNA - Visual evoked potentials - Scheimpflug principle

Users

- IOL manufacturers - Eye test and imaging companies - Ophthalmologists

Keywords

Lens epithelial cells, Aniseikonia, Eye test

Van Nuffelen Gwen

My main research topics are related to 1) assessment and treatment of dysphagia in head and neck cancer patients and patients with neurological diseases 2) assessment and treatment of motor speech disorders including training algorithms and neural networks for that purpose 3) assessment and treatment of voice disorders

Technique

- profound experience in multidisciplinary and/or multicenter randomized, controlled trials & prospective cohort studies - thorough experience in prophylactic studies in HNC-patients treated with RT/C - objective measurements of tongue strength & strength of the suprahyoid muscles - instrumental evaluation of swallowing by means of FEES end VFES - instrumental analysis of vocal fold behavior and condition by means of stroboscopy - acoustic analysis of speech and voice - objective analysis of intelligibility - automated analysis of articulatory skills - standardized questionnaires to assess QoL and participation related to voice, swallowing and speech

Users

Our research is direct towards - patients with head and neck cancer treated with CCRT or surgery - patients with neurological diseases - patients with voice disorders - patients with impairments that lead to swallowing, speech or voice disorders - groups that are vulnerable to swallowing disorders (e.g. men/women 65+) - professional (e.g.teachers) and elite (e.g. singers) vocal performers

Keywords

Experimental study, Innovations, Communication, Motor speech disorders, Swallowing disorders, Voice disorders, Speech

Van Ombergen Angelique

Investigating the effect of spaceflight on the brain of astronauts and the effect of vestibular disorders on the brain of vestibular patients.

Technique

vestibular clinical testing brain scans (MRI)

Users

media patients (vestibular) astronauts general audience children & youngsters

Keywords

Vestibular, Human vestibular research, Otovestibular pathology, Spaceflight, Aerospace, Brain, Neuroscience, Vestibular system

Van Rompaey Vincent

Transgenic animal models for hereditary hearing loss and vestibular failure (DFNA9, COCH). Animal models for acquired hearing loss and vestibular failure. Measuring hearing by auditory brainstem recording, startle-reflex and distortion product oto-acoustic emissions. Measuring attention and tinnitus by prepulse-inhibition. Measuring balance by means of behavioral and reflex testing. Clinical audiovestibular evaluation/ Cognitive evaluation by means of the RBANS-H. Spatial navigation by means of the virtual Morris Water Task. Evaluation of tinnitus. Robotic-assisted cochlear implantation. Menière’s disease and bilateral vestibulopathy.

Technique

Rodent auditory brainstem recording and distortion product oto-acoustic emissions to test hearing, behavioral assessment of vestibular function, prepulse inhibition for tinnitus analysis, cochlear dissection. State-of-the-art auditory testing, incl. liminal audiometry, speech audiometry in quiet and in noise, auditory brainstem recording, cortical auditory-evoked (late) potentials, assessment of cognitive function adapted to a potentially hearing-impaired population. -Tinnitus analysis, incl. validated patient reported outcome measures, pitch matching, non-invasieve neuromodulation (hd-tDCS). -Vestibular evaluation, incl. electronystagmography, VEMP, 3D video head impulse testing, video-oculography, balance testing, spatial navigation (virtual Morris water Task).

Users

Translational research into treating or preventing hearing loss and vestibular dysfunction.

Keywords

Balance, Cognition, Hearing loss, Vestibular system, Gene therapy

Van de Heyning Paul

Audiological/otoneurophysiologiccal investigations, vestibular testing of semicircular canal function and otolyth function and speech analysis.

Technique

- Otlyth research - Cochlear function testing - MVDP speech and voice analysis

Users

- Farmaceutical inustry - ENT specialists - Otoneurophysiologists - Aerospacial medicine - Sleeplaboratories

Keywords

Otophysiological research, Balance disorders, Speech, Upper airway

Van den Bogerd Bert

The expertise of dr. Bert Van den Bogerd lies within the field of regenerative medicine and developing innovative cell therapies. Specifically, dr. Van den Bogerd has been investigating a new substrate to grow and transplant corneal endothelial cells on, which consist of poly-(D,L)-lactic acid. This development and characterization of this new materials has been done in collaboration with the University of Ghent.

Technique

- Immunocytochemistry - high-throughput live cell imaging - Primary corneal cell culture - Tissue engineering

Users

People who are interested in biomaterials and tissue engineering the anterior segment of the eye are welcome to contact me.

Keywords

Ophthalmic drugs, Advanced materials, Corneal regeneration

Yperzeele Laetitia

*Clinical stroke research focusing on prehospital diagnostics (telemedicine), wearables (HRV measurement) and predictors of outcome (gait analysis, DTI imaging techniques). *Participation in international databases and consortia (BEL-FMD, NOAC-ISP, SiFAP) *Prinical investigator / national coordinator for industry-led RCT's (eg. THALES, NAVIGATE-ESUS, ETNA-AF, RESTORE BRAIN, AXIOMATIC-SSP trial).

Technique

*clinical RCT's, Phase II /III/IV *prospective cohortstudies *qualitative research *epidemiological research

Users

*clinical practitioners, stroke physicians, paramedics

Keywords

Neurotrauma, Neuroplasticity, Neuronal microcircuits, Neuro mri, Neurosurgery, Vascular research, Neuro-imaging, Stroke