This page lists some of the expertise of our research members. Contents are automatically generated from the central databases of the University of Antwerp. Contact the individual staff members for more info.
Neurogenetics, molecular genetics, neuropathology, clinical neurology, clinical neurophysiology
Techniquemolecular genetics, histopathology, clinical neurophysiology
Usersneurologists, neuroscientists, geneticists
Genetic disease, Pathomechanism, Neuropathology, Neuro muscular diseases, Hereditary neuropathies
Research on congenital hearing loss in collaboration with the department of Medical Genetics of the University of Antwerp. Research on airway problems and sleep-related breathing disorders in children with Down syndrome in collaboration with the department of Pediatrics at the Antwerp University Hospital. Research on pediatric sleep disordered breathing in collaboration with the department of pediatrics of the Antwerp University Hospital and international collaboration with the European Respiratory Society (ERS) Pediatric Sleep Group.
Techniquesleep endoscopy and direct laryngoscopy polysomnography
Userspediatricians, ENT surgeons
Dynamic / cyclic loading of mini-samples at low loads and evaluation of dental damage.
Technique- Flexural fatigue - Micro-shear fatigue - Servo-hydraulic puls fatigue machine for heavy loads
Users- ENT: study of small hearing bones - Orthopedics: study of fixation material
Forensics, Composites, Dental materials, Fatigue, Dentistry, Adhesive agent
Epilepsy in children: clinical, genetic and treatment aspects. Fenfluramine as new anticonvulsive treatment. Dravet syndrome: clinical aspects.
TechniqueClinical. We do not do lab examinations.
UsersExpertise in all aspecyts from epilepsies in children.
Child development, Epileptic encephalopathies, Epilepsy gene, Epilepsy, Genetics, Anticonvulsants
Neuropathology of human and animal nervous system, immunohistochemistry of nervous system specific proteins, immunodiagnosis of cerebrospinal fluid, enzyme linked immunoassay protein TAU and amyloid-beta, immunoblotting of 14-3-3.
Technique- Light- and electronenmicroscopy - Histochemistry - Immunohistochemistry - Ultramicrotomy - Immunoblotting - Enzyme linked immunoassay - Chromatographic techniques
Users- Neuroscientists - Biomedical scientists - Biologists - Veterinarians - Medical doctors
Parkinsons disease, Dementia, Prion disease, Electron microscopy, Epidemiology, Immunocytochemistry, Neurology, Neuropathology, Enzymes
Clinical neurology, neurogenetics, molecular genetics, movement disorders, neurodegenerative brain diseases, Parkinson's disease, dystonia, tremor
Techniqueclinical research, molecular genetics
UsersPhysicians, paramedical professions, neurologists, neuroscientists, geneticists
Genotype-phenotype correlation, Parkinsons disease, Neurology, Genetics
De Groot Veva
Clinical glaucoma studies. Research concerning optic disc, and influence CSV on glaucoma
TechniqueOCT visual field fundus exam visual acuity eye pressure
Userscolleagues companies producing glaucoma medication
The Antwerp Research Group for Ocular Science (ARGOS) focuses on translational research of the anterior segment of the eye using techniques of regenerative medicine and tissue engineering. We conduct projects from bench to bed side by a unique combination of clinicians and basic researchers. Our focus is on the ocular surface with research lines on regeneration of the epithelium, stroma and endothelium of the cornea and conjunctiva. The approach is multidisciplinary thanks to local, national and international network connections. Our expertise includes the development and optimization of primary cell isolation and cell culture protocols without using animal products, designing biological and synthetic scaffolds, and testing their biocompatibility. Through our partnerships, we have the opportunity to work with 3D printing, micro-contact printing and with different types of hydrogels. Specifically, we successfully completed a phase I / II study in which limbal corneal epithelial stem cells were expanded ex vivo on an amniotic membrane for transplantation. We are further building on the acquired expertise: we are specifically focused on the development of a conjunctival substitute and smart scaffolds for endothelial transplantation. The latest project concerns cornea-on-chip in which a three-dimensional dynamic tissue environment is created to better model human physiology in a lab environment. The Visual Optics Lab Antwerp (VOLANTIS) studies the optical aspects of the human eye, with special attention to normal and pathological refractive development. To this end, we develop statistical and biomechanical models that innovatively describe normal eye growth, as well as the inter-individual differences that exist in the general population to better understand myopia and other refractive disorders. The unique collaboration between clinicians, optometrists, mathematicians, and physicists has already led to fundamental advances in the early detection of keratoconus and predicting the future course of the disease, allowing individualized treatment to be offered to the patient. Another line of research focuses on how glare from bright lights can affect daily functioning in tasks such as driving a vehicle safely. Finally, research is also being carried out on pediatric cataracts to gain more pathophysiological insight into this developmental disorder and the results of the surgical treatment.
TechniqueArgos: cel culture, immunohisto-/cytochemistry, PCR and high throughput live cell imaging. Volantis: prospective and retrospective data collection in the clinic, statistical models and analysis, ray tracing, finite element modeling, machine learning.
UsersClinicians and researchers involved in ophthalmology, at home and abroad. Specifically for Argos: researchers interested in tissue engineering and regenerative medicine.
Corneal regeneration, Optical eye modelling
Large database with individual patient data of traumatic brain injuries (IMPACT database).
TechniqueAccess to the data can be provided following submission of research questions and establishment of an agreement on data use.
UsersResearchers in the field of traumatic brain injury.
Prognosis, Brain trauma, Neurosurgery, Clinical study
In the coming years the VOLANTIS research group, plans to conduct several studies related to visual optics and ocular biomechanics. Overall, these studies may be grouped into three topics. The first is refractive development and eye modelling, which studies how the eye grows and how this can be described as a mathematical model. Such models will look at e.g. how during eye growth the different components of ocular biometry interact with each other to first bring the eye in focus ('emmetropia') and then maintain this condition as the eye continues to grow. Other studies look at what happens if such a balance is disrupted or how it is accomplished in pathological eyes (e.g. premature infants or infants operated for cataract). Within the European OBERON project, we will also develop a new type of model that combines the biomechanics of the eye with its optical function as a platform for testing new treatments in virtual clinical trials. This 'opto-biomechanical' model will need close interactions with our European partners. The next study topic is keratoconus, a disease that gradually deforms the cornea, leading to a considerable loss in visual quality. Early detection of the disease and its possible progression is very important in its management as it allows the patients to preserve a higher visual quality through timely treatment. To this end, we are working on machine learning systems that can tell ophthalmologists whether an eye has keratoconus and, if so, if it is in a progressive state. Another project looks at improving the popular 'crosslinking' treatment that increases corneal elasticity and stops the progression. To do this, we need to develop corneal elasticity maps that can inform ophthalmologists what areas of the cornea need treatment. Although the current methods to develop such maps are very computationally intensive, we will use new methods that have not yet been tried to speed up this process from several hours to minutes, making it clinically useful. Finally, we will study straylight and dark adaptation, which refers to being blinded by bright lights ('glare') and the time needed to recover afterwards. These phenomena can play a major role in traffic safety as drivers may be blinded by the headlights of oncoming cars. Since it is not yet understood at what level of glare the safety risks for safe driving become too high, we will organize a study to test the effect of a bright light source on performance in a driving simulator in a darkened room. The outcomes of these experiments will later be formulated as advice to legislative authorities to improve traffic safety.
TechniqueClinical eye measurements Eye modelling
UsersResearchers, doctors, journalists
Visual optics, Myopia, Eye modelling
Lens and lens capsule Biometry Epidemiology of refraction and biometry Physiological optics Keratoconus IOL exchange Glaucoma Densitometry Quality of vision Artificial iris Floaters Macular edema Straylight Thyroid associated ophthalmopathy and VEP Genetic characteristics of the lens capsule Genetic characteristics of keratoconus patients Statistical eye models (adults, children) Stem cell transplantation Biocornea
Technique- Aberrometer - OCT - Biometer - New Generation Sequencing for RNA/DNA - Visual evoked potentials - Scheimpflug principle
Users- IOL manufacturers - Eye test and imaging companies - Ophthalmologists
Lens epithelial cells, Aniseikonia, Eye test
Van Nuffelen Gwen
My main research topics are related to 1) assessment and treatment of dysphagia in head and neck cancer patients and patients with neurological diseases 2) assessment and treatment of motor speech disorders including training algorithms and neural networks for that purpose 3) assessment and treatment of voice disorders
Technique- profound experience in multidisciplinary and/or multicenter randomized, controlled trials & prospective cohort studies - thorough experience in prophylactic studies in HNC-patients treated with RT/C - objective measurements of tongue strength & strength of the suprahyoid muscles - instrumental evaluation of swallowing by means of FEES end VFES - instrumental analysis of vocal fold behavior and condition by means of stroboscopy - acoustic analysis of speech and voice - objective analysis of intelligibility - automated analysis of articulatory skills - standardized questionnaires to assess QoL and participation related to voice, swallowing and speech
UsersOur research is direct towards - patients with head and neck cancer treated with CCRT or surgery - patients with neurological diseases - patients with voice disorders - patients with impairments that lead to swallowing, speech or voice disorders - groups that are vulnerable to swallowing disorders (e.g. men/women 65+) - professional (e.g.teachers) and elite (e.g. singers) vocal performers
Experimental study, Innovations, Communication, Motor speech disorders, Swallowing disorders, Voice disorders, Speech
Van Ombergen Angelique
Investigating the effect of spaceflight on the brain of astronauts and the effect of vestibular disorders on the brain of vestibular patients.
Techniquevestibular clinical testing brain scans (MRI)
Usersmedia patients (vestibular) astronauts general audience children & youngsters
Vestibular, Human vestibular research, Otovestibular pathology, Spaceflight, Aerospace, Brain, Neuroscience, Vestibular system
Van Rompaey Vincent
Transgenic animal models for hereditary hearing loss and vestibular failure (DFNA9, COCH). Animal models for acquired hearing loss and vestibular failure. Measuring hearing by auditory brainstem recording, startle-reflex and distortion product oto-acoustic emissions. Measuring attention and tinnitus by prepulse-inhibition. Measuring balance by means of behavioral and reflex testing. Clinical audiovestibular evaluation/ Cognitive evaluation by means of the RBANS-H. Spatial navigation by means of the virtual Morris Water Task. Evaluation of tinnitus. Robotic-assisted cochlear implantation. Menière’s disease and bilateral vestibulopathy.
TechniqueRodent auditory brainstem recording and distortion product oto-acoustic emissions to test hearing, behavioral assessment of vestibular function, prepulse inhibition for tinnitus analysis, cochlear dissection. State-of-the-art auditory testing, incl. liminal audiometry, speech audiometry in quiet and in noise, auditory brainstem recording, cortical auditory-evoked (late) potentials, assessment of cognitive function adapted to a potentially hearing-impaired population. -Tinnitus analysis, incl. validated patient reported outcome measures, pitch matching, non-invasieve neuromodulation (hd-tDCS). -Vestibular evaluation, incl. electronystagmography, VEMP, 3D video head impulse testing, video-oculography, balance testing, spatial navigation (virtual Morris water Task).
UsersTranslational research into treating or preventing hearing loss and vestibular dysfunction.
Balance, Cognition, Hearing loss, Vestibular system, Gene therapy
Van de Heyning Paul
Audiological/otoneurophysiologiccal investigations, vestibular testing of semicircular canal function and otolyth function and speech analysis.
Technique- Otlyth research - Cochlear function testing - MVDP speech and voice analysis
Users- Farmaceutical inustry - ENT specialists - Otoneurophysiologists - Aerospacial medicine - Sleeplaboratories
Otophysiological research, Balance disorders, Speech, Upper airway
Van den Bogerd Bert
The expertise of dr. Bert Van den Bogerd lies within the field of regenerative medicine and developing innovative cell therapies. Specifically, dr. Van den Bogerd has been investigating a new substrate to grow and transplant corneal endothelial cells on, which consist of poly-(D,L)-lactic acid. This development and characterization of this new materials has been done in collaboration with the University of Ghent.
Technique- Immunocytochemistry - high-throughput live cell imaging - Primary corneal cell culture - Tissue engineering
UsersPeople who are interested in biomaterials and tissue engineering the anterior segment of the eye are welcome to contact me.
Ophthalmic drugs, Advanced materials, Corneal regeneration
*Clinical stroke research focusing on prehospital diagnostics (telemedicine), wearables (HRV measurement) and predictors of outcome (gait analysis, DTI imaging techniques). *Participation in international databases and consortia (BEL-FMD, NOAC-ISP, SiFAP) *Prinical investigator / national coordinator for industry-led RCT's (eg. THALES, NAVIGATE-ESUS, ETNA-AF, RESTORE BRAIN, AXIOMATIC-SSP trial).
Technique*clinical RCT's, Phase II /III/IV *prospective cohortstudies *qualitative research *epidemiological research
Users*clinical practitioners, stroke physicians, paramedics
Neurotrauma, Neuroplasticity, Neuronal microcircuits, Neuro mri, Neurosurgery, Vascular research, Neuro-imaging, Stroke