Departement: Departement Biomedische Wetenschappen
Microglia-synapse molecular interactions in neurodegenerative disorders
About the labs
The Mancuso lab (Microglia and Inflammation in Neurological Disorders, MIND) at the VIB-UAntwerp Center for Molecular Neurology and the De Wit lab (Laboratory of Synapse Biology) at the VIB-KU Leuven Center for Brain & Disease Research, Belgium, are seeking a highly motivated postdoctoral fellow to work on a project on microglia-synapse interactions in neurodegenerative disorders.
About the project
Microglia and neuroinflammation play a central role in the pathogenesis of Alzheimer’s disease and other neurodegenerative disorders. Microglia interactions with synapses are essential for neural circuit development and function, but the role and molecular mechanisms of microglia-synapse interactions in the pathogenesis of neurodegenerative disorders remain poorly understood. This project will use mouse models, multi-omics approaches, iPSC and cutting-edge humanized mouse systems to unravel how microglia-synapse interactions contribute to the initiation and perpetuation of neurodegenerative disease.
This is a project at the interface of two labs: the Mancuso lab, working on human and mouse microglia biology in brain disorders, and the Laboratory of Synapse Biology working on the molecular mechanisms that control precise synaptic connectivity in healthy and diseased neural circuits (see references below). In this project, you will make use of innovative multi-omics approaches, genome engineering, viral vector technology, iPSC and humanized mouse technology to unravel the role and molecular mechanisms of microglia-synapse interactions in neurodegenerative disorders. The successful applicant will work in both labs and divide the time between the two sites.
- Mancuso et al. Nat Neurosci (2019). 22:2111-2116
- Fattorelli, Martinez Muriana et al. Nat Protocols (2020), in press
- Apóstolo et al. Nat Commun (2020). 11(1):5171
- Rice et al. Science (2019). 363(6423)
- Condomitti et al. Neuron (2018). 100:201-215
We are seeking a highly motivated, enthusiastic, critical and creative individual to join our teams. The candidate should have a strong interest in neurobiology.
- PhD in neurobiology (molecular, cellular, developmental, systems) or related disciplines
- A solid publication record with first-author research publication(s) in peer-reviewed international journals
- Team player
Desirable but not required:
- Prior experience with mouse neurobiology and molecular biology
- Prior experience with transcriptomics, proteomics or bioinformatics
- Prior experience with iPSC biology
- Prior experience with microglia biology
- A versatile and challenging job in a vibrant, world-class research environment operating at an international level
- State of the art research facilities
- A dedicated training program to broaden your expertise and enhance your skill set
- A competitive compensation package based on expertise and experience
- Financial support for at least 2 years. The successful candidate is encouraged to obtain a personal fellowship (Marie-Curie, HFSP, EMBO, or national funding organizations)
- Starting Date: as soon as possible
How to apply?
- You can apply for this vacancy through the University of Antwerp’s online job application platform. Click on the 'Apply' button, complete the online application form and be sure to include the following attachments: a motivation letter, a detailed CV incl. list of publications, and the contact information of three referees.
- The selection committee will review all of the applications as soon as possible after the application deadline. As soon as a decision has been made, we will inform you about the next steps in the selection procedure.
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The University of Antwerp received the European Commission’s HR Excellence in Research Award for its HR policy. We are a sustainable, family-friendly organisation which invests in its employees’ growth. We encourage diversity and attach great importance to an inclusive working environment and equal opportunities, regardless of gender identity, disability, race, ethnicity, religion or belief, sexual orientation or age. We encourage people from diverse backgrounds and with diverse characteristics to apply.