Self-sufficient primary natural killer cells engineered to express T cell receptors and interleukin-15 exhibit improved effector function and persistence

Bron
Frontiers in immunology - ISSN 1664-3224-15 (2024) p.
Auteur(s)
    Els P. van Hees, Laura T. Morton, Dennis F. G. Remst, Anne K. Wouters, Astrid Van den Eynde, J. H. Frederik Falkenburg, Mirjam H. M. Heemskerk

IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts

Bron
Journal of hematology and oncology - ISSN 1756-8722-17:1 (2024) p. 1-19