Full Professor of Neurosciences and Neurochemistry, Department of Biomedical Sciences, University of Antwerp
Director, Reference Center for Biological Markers of Dementia (BIODEM), Department of Biomedical Sciences, University of Antwerp
Coordinator of Memory Clinic, Department of Neurology, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken
- MD, Free University of Brussels (V.U.B.), 1995
- Neurologist (Belgian Board Certification), University of Antwerp, 2001
- PhD in Medical Sciences, University of Antwerp, 2004
- Specialist in Neurological Revalidation (Belgian Board Certification), UAntwerp, 2009
Sebastiaan Engelborghs was born on September 21st, 1970 in Brussels, Belgium. He obtained his degree as medical doctor with summa cum laude in 1995 at the Free University of Brussels (V.U.B.). He then followed a Master after Master in Clinical Neurology and became a board certified neurologist in 2001 at UAntwerp where he also obtained a PhD in medical sciences (2004). In 2004, he established the Reference Centre for Biological Markers of Dementia (BIODEM) at UAntwerp and was appointed assistant professor. In 2008, Dr. Engelborghs was promoted to associate professor and became coordinator of the Memory Clinic, Department of Neurology, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken. He was board certified in Neurological Revalidation in 2009. In 2011, he was appointed research professor neurosciences – neurochemistry at the University of Antwerp and became full professor neurosciences – neurochemistry in 2014.
The BIODEM lab now consists of a research and service lab, the latter offering CSF biomarker analyses for (differential) diagnosis of AD to referring clinical labs and medical specialists throughout Belgium, as well as for clinical trials. The BIODEM research lab focusses on improving existing biochemical and existing biomarkers for AD and related disorders as well as on innovative biomarkers. Besides the PI, the BIODEM lab now counts one assistant professor, one visiting professor, 1 postdoctoral research manager, 1 postdoctoral researcher, 6 PhD students, 2 MD research assistants and 1 lab technician.
Both clinically and with regard to research, Sebastiaan Engelborghs is specialized in neurodegenerative brain disorders that cause cognitive impairment and dementia. Since 2008, Sebastiaan Engelborghs coordinates the Memory Clinic of the Department of Neurology of ZNA Middelheim and Hoge Beuken, which consists of an outpatient unit, three inpatient units of in total 60 beds, and a phase II / III clinical trial unit for Alzheimer’s disease. His research resulted in (co-)authorships on 278 PubMed-cited papers in international peer-reviewed journals and an h-index of 52 (April 2018). Research initially focused on the validation of existing CSF biomarkers for AD and the BIODEM lab was the first to validate these biomarkers in autopsy-confirmed patients. Several studies on standardization and harmonization of (the pre-analytical and analytical steps of) CSF biomarker analyses were published. His research has significantly contributed to the integration of AD CSF biomarkers into the research diagnostic criteria of AD, like the IWG criteria that he co-authored.
Sebastiaan Engelborghs is laureate of several prices and awards and is board member of several national and international professional organizations. He is seceratry-general of the Belgian Neurological Society and is an ExCo member of the European Alzheimer Disease Consortium.