Medicinal Chemistry search menu search content Exploratory protease targets Prolyl specific peptidases This small family of peptidases has been in the interest of UAMC and the research group of medical biochemistry (UA) since the 1980’s. Our group pioneered in the synthesis of potent and selective…

Martijn Willemsen predoc researcher FWO Research Martijn Willemsen Research team Medicinal Chemistry (UAMC) Potent intra-tumoral autophagy blocking with kinase PROTACs and inhibitors. 01/11/2023 - 31/10/2025 Abstract In tumors, autophagy acts as a survival mechanism that protects tumor cells from cy…

Lidia Carotenuto postdoctoraal bursaal Publicaties Lidia Carotenuto Kv7 channel activation reduces brain endothelial cell permeability and prevents kainic acid-induced blood-brain barrier damage Bron American journal of physiology : cell physiology - ISSN 0363-6143-326:3 (2024) p. C893-C904 Auteur(s…

Medicinal Chemistry search menu search content Infectious diseases HIV/AIDS In the framework of a large EU-FP7 research project on the development of microbicides for the prevention of HIV/AIDS (CHAARM) we developed a series of novel and highly interesting non-nucleoside reverse transcriptase inhibi…

Alba Ramos Llorca unpaid staff Research Alba Ramos Llorca Research team Medicinal Chemistry (UAMC) Design, Synthesis and Biochemical evaluation of novel serine protease activity-based probes. 01/10/2021 - 30/09/2022 Abstract Serine proteases are a subgroup of the protease family involved in several …

Sophie Lyssens expert Publicaties Sophie Lyssens ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice Bron Biochemical pharmacology - ISSN 0006-2952-138 (2017) p. 150-162 Auteur(s) Ammar Kurdi, Matthias Cleenewerck, Christel Vangestel, …

Medicinal Chemistry search menu search content Cell death/survival Necroptosis and Ferroptosis Necroptosis and ferroptosis are newly discovered modes of regulated necrosis. Necroptosis is regulated by RIP kinase 1 (RIP1) and plays a critical role in several inflammatory diseases. Furthermore, RIP1 h…

Greta Klejborowska senior onderzoeker Publicaties Greta Klejborowska Beyond ferrostatin-1 : a comprehensive review of ferroptosis inhibitors Bron Trends in pharmacological sciences - ISSN 0165-6147-44:12 (2023) p. 902-916 Auteur(s) Camilla Scarpellini, Greta Klejborowska, Caroline Lanthier, Behrouz …

Camilla Scarpellini senior onderzoeker Publicaties Camilla Scarpellini Beyond ferrostatin-1 : a comprehensive review of ferroptosis inhibitors Bron Trends in pharmacological sciences - ISSN 0165-6147-44:12 (2023) p. 902-916 Auteur(s) Camilla Scarpellini, Greta Klejborowska, Caroline Lanthier, Behrou…

Quanyi Yu doctoraatsbursaal Onderzoek Quanyi Yu Onderzoeksgroep Moleculaire Beeldvorming en Radiologie (MIRA) TheraCuSe: Ontwikkelen van een theranostische pre-targetingstrategie met 64Cu/67Cu voor CD70-exprimerende soliede tumoren. 01/10/2023 - 30/09/2027 Abstract Despite recent progress, an unmet …

An Matheeussen expert Publicaties An Matheeussen Discovery of a series of macrocycles as potent inhibitors of Leishmania infantum Bron Journal of medicinal chemistry - ISSN 0022-2623-67:20 (2024) p. 18170-18193 Auteur(s) Federico Riu, Larissa Alena Ruppitsch, Duc Duy Vo, Richard S. Hong, Mohit Tyagi…

Steven Weekx gastprofessor Publicaties Steven Weekx Generation of T-cells from adult human hematopoietic stem cells and progenitors in a fetal thymic organ culture system: stimulation by tumor necrosis factor-α Bron Blood - ISSN 0006-4971-95 (2000) p. 2806-2812 Auteur(s) Steven Weekx, H.W. Snoeck, …

Sarah Hendrickx onderwijscoördinator Publicaties Sarah Hendrickx Discovery of a series of macrocycles as potent inhibitors of Leishmania infantum Bron Journal of medicinal chemistry - ISSN 0022-2623-67:20 (2024) p. 18170-18193 Auteur(s) Federico Riu, Larissa Alena Ruppitsch, Duc Duy Vo, Richard S. …

Koen Augustyns full professor Koen Augustyns PhD Students 26/09/2000 Gabrielle Thonus: Design, synthesis and biological evaluation of opioid-related prolyl peptides and pseudopeptides 10/11/2000 XueMei Zhang: Design, synthesis and evaluation of dipeptidyl peptidase IV (DPP IV) inhibitors 25/06/2002 …

Greta Klejborowska senior researcher Research Greta Klejborowska Research team Medicinal Chemistry (UAMC) Expertise I am a PhD chemist particularly interested in medicinal chemistry with broad experience in organic synthesis (small molecules, natural product derivatives, tumour-targeting drug conjug…

Cell Death Signaling search menu search content Molecular actions of medicinal compounds Systems biology based characterization of medicinal effects of phytochemicals Epidemiological, clinical and animal studies support a beneficial role of mangiferin, epicatechin and withaferin A in the prevention …

Jordan Donat researcher Research Jordan Donat Research team Organic synthesis (ORSY) Expertise Studies in Organic and inorganic chemistry: Bachelor, Master, PhD, Post Doc Industry, Post Doc academy. Research activity: - C-H activation, Nitrene transfer catalysis. Analysis: UV-vis, Mass Spectrometry …

Anke de Groot doctoral scholarship holder Research Anke de Groot Research team Medical Biochemistry FAPI-PLA: Accelerating the preclinical development of fibroblast-activation protein (FAP)-targeted theranostics through a highly interdisciplinary in vitro platform. 01/11/2024 - 31/10/2027 Abstract F…

Camilla Scarpellini senior researcher Research Camilla Scarpellini Research team Medicinal Chemistry (UAMC) Design, synthesis and biological evaluation of novel ferroptosis and necroptosis inhibitors. 01/10/2021 - 30/09/2022 Abstract Different types of cells deaths play a key role in the pathogenesi…

Freke Mertens predoc researcher FWO Research Freke Mertens Research team Physiopharmacology (PHYSPHAR) Characterization and validation of novel autophagy inducers identified via high-throughput screening: a therapeutic option for the treatment of advanced atherosclerosis. 01/11/2023 - 31/10/2025 Abs…

Line De Vocht predoc researcher FWO Research Line De Vocht Research team Medical Biochemistry Identification of potent single-domain antibodies against the malaria sporozoite through a synthetic single-domain antibody library containing unconventional diversification strategies. 01/11/2023 - 31/10/2…

Informatie voor bedrijven zoeken menu zoek inhoud Life sciences Licentieaanbod Highly selective, orally bioavailable inhibitors of fibroblast activation protein (FAP) with development potential in fibrosis, oncology and pathologic tissue remodeling The University of Antwerp has discovered the most p…

Sophie Lyssens expert Publications Sophie Lyssens ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice Source Biochemical pharmacology - ISSN 0006-2952-138 (2017) p. 150-162 Author(s) Ammar Kurdi, Matthias Cleenewerck, Christel Vangeste…

Informatie voor bedrijven zoeken menu zoek inhoud Life sciences Licentieaanbod Safe, effective and oral treatment against parasitic infections Situation before Protozoa are a group of single-celled eukaryotes, either free-living or parasitic, that can cause disease in both humans and animals such as…

Cardiovascular Diseases search menu search content Reperfusion Injury and Cardiac Remodelling after Acute Myocardial Infarction Reperfusion Injury and Cardiac Remodelling after Acute Myocardial Infarction Early recanalization of an occluded infarct vessel is the main target in the acute management o…