Medicinal Chemistry search menu search content Exploratory protease targets Prolyl specific peptidases This small family of peptidases has been in the interest of UAMC and the research group of medical biochemistry (UA) since the 1980’s. Our group pioneered in the synthesis of potent and selective…

Martijn Willemsen predoc researcher FWO Research Martijn Willemsen Research team Medicinal Chemistry (UAMC) Potent intra-tumoral autophagy blocking with kinase PROTACs and inhibitors. 01/11/2023 - 31/10/2027 Abstract In tumors, autophagy acts as a survival mechanism that protects tumor cells from cy…

Sarah Peeters predoc mandaat FWO Publicaties Sarah Peeters Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potential Bron Journal of me…

Koen Augustyns gewoon hoogleraar Publicaties Koen Augustyns Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potential Bron Journal of m…

Medicinal Chemistry search menu search content Infectious diseases HIV/AIDS In the framework of a large EU-FP7 research project on the development of microbicides for the prevention of HIV/AIDS (CHAARM) we developed a series of novel and highly interesting non-nucleoside reverse transcriptase inhibi…

Alba Ramos Llorca unpaid staff Research Alba Ramos Llorca Research team Medicinal Chemistry (UAMC) Design, Synthesis and Biochemical evaluation of novel serine protease activity-based probes. 01/10/2021 - 30/09/2022 Abstract Serine proteases are a subgroup of the protease family involved in several …

Medicinal Chemistry search menu search content Cell death/survival Necroptosis and Ferroptosis Necroptosis and ferroptosis are newly discovered modes of regulated necrosis. Necroptosis is regulated by RIP kinase 1 (RIP1) and plays a critical role in several inflammatory diseases. Furthermore, RIP1 h…

Adrian Fabisiak postdoctoraal bursaal Publicaties Adrian Fabisiak Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potential Bron Journa…

Pawel Brzeminski postdoctoraal bursaal Publicaties Pawel Brzeminski Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potential Bron Jour…

Roberta Pacifico postdoctoraal bursaal Publicaties Roberta Pacifico Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potential Bron Jour…

Kim Van Meel doctoraatsbursaal Publicaties Kim Van Meel Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potential Bron Journal of medic…

Sarah Peeters predoc researcher FWO Publications Sarah Peeters Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potential Source Journal…

Sophie Lyssens expert Publicaties Sophie Lyssens ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice Bron Biochemical pharmacology - ISSN 0006-2952-138 (2017) p. 150-162 Auteur(s) Ammar Kurdi, Matthias Cleenewerck, Christel Vangestel, …

Koen Augustyns full professor Koen Augustyns PhD Students 26/09/2000 Gabrielle Thonus: Design, synthesis and biological evaluation of opioid-related prolyl peptides and pseudopeptides 10/11/2000 XueMei Zhang: Design, synthesis and evaluation of dipeptidyl peptidase IV (DPP IV) inhibitors 25/06/2002 …

Koen Augustyns full professor Publications Koen Augustyns Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potential Source Journal of m…

Pawel Brzeminski postdoctoral scholarship hold. Research Pawel Brzeminski Research team Medicinal Chemistry (UAMC) Next generation ketoamide inhibitors of fibroblast activation protein (FAP) to revolutionize radionuclide therapy in cancer (KetoFAPIs). 01/11/2024 - 31/10/2026 Abstract Fibroblast acti…

Dominik Halter tenure track docent Publicaties Dominik Halter Generative deep learning pipeline yields potent gram-negative antibiotics Bron JACS Au - ISSN 2691-3704-5:9 (2025) p. 4249-4259 Auteur(s) Martin F. Kollen, Maximilian G. Schuh, Robin Kretschmer, Joshua Hesse, Dominik Schum, Junhong Chen, …

Camilla Scarpellini senior onderzoeker Publicaties Camilla Scarpellini Oxazole-based ferroptosis inhibitors with promising properties to treat central nervous system diseases Bron Journal of medicinal chemistry - ISSN 0022-2623-68:4 (2025) p. 4908-4928 Auteur(s) Camilla Scarpellini, Greta Klejborows…

Anne-Marie Lambeir emeritus occasionele opdracht Publicaties Anne-Marie Lambeir Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potenti…

Hans De Winter hoogleraar Publicaties Hans De Winter C2PO : an ML-powered optimizer of the membrane permeability of cyclic peptides through chemical modification Bron Journal of Cheminformatics - ISSN 1758-2946-17:1 (2025) p. 1-13 Auteur(s) Roy Aerts, Joris Tavernier, Alan Kerstjens, Mazen Ahmad, Jo…

Kayhan Ilbeigi senior onderzoeker Publicaties Kayhan Ilbeigi Thiazolidinones and related analogues as efficient antitrypanosomal agents Bron Bioorganic and medicinal chemistry - ISSN 0968-0896-130 (2025) p. 1-18 Auteur(s) Michal Kolarik, Kayhan Ilbeigi, Guy Caljon, Lucie Brulikova Citatielink Sustai…

Tim Boogaerts postdoc mandaat FWO Publicaties Tim Boogaerts Nontarget and suspect screening of fluorinated ionic liquids and PFAS in European wastewaters using supercritical fluid chromatography Bron Environmental science and technology - ISSN 0013-936X-59:39 (2025) p. 21300-21311 Auteur(s) Selina T…

Dorien Mabille postdoc mandaat FWO Publicaties Dorien Mabille 3′-deoxytubercidin : a potent therapeutic candidate for the treatment of Surra and Dourine Bron International Journal for Parasitology: Drugs and Drug Resistance - ISSN 2211-3207-27 (2025) p. 1-5 Auteur(s) Kayhan Ilbeigi, Dorien Mabille…

Jordan Donat unpaid staff Research Jordan Donat Research team Organic synthesis (ORSY) Expertise Studies in Organic and inorganic chemistry: Bachelor, Master, PhD, Post Doc Industry, Post Doc academy. Research activity: - C-H activation, Nitrene transfer catalysis. Analysis: UV-vis, Mass Spectrometr…

Ingrid De Meester gewoon hoogleraar Publicaties Ingrid De Meester Structure-property investigation of new "KetoFAPI" inhibitors of fibroblast activation protein (FAP) : discovery of highly potent, selective compounds with prolonged residence times and promising radiotheranostic potential Bron Journa…