01/12/2021 - Elham

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Wireless monitoring with implantable telemetry devices enables animals to freely move without external disturbances during safety pharmacology experiments. This technique increases animal welfare by allowing a continuous recording of their cardiovascular parameters with just one implantable microchip and a receiver in close proximity to the housing unit. But, what about if we could give the animals more space in that they could even exceed the range of the receiver? 

Telemetry-based implants with internal memory offer us to remotely record cardiovascular data away from the receiver without losing data. During cardiovascular experiments, laboratory animals can move around freely with flexibility in the location, and all the data will be continuously collected in the implanted memory chip. Data will be transmitted whenever the implant is within range of the receiver. This free movement increases the life quality of laboratory animals by playing around and interact together, which contributes to 3Rs (replacement, refinement, and reduction) in in-vivo experiments. Consequently, it has a positive effect on reliability and accuracy of cardiovascular data in safety pharmacology studies.

During my Ph.D. project, I will investigate this telemetry system, with the ability to store real-time cardiovascular data in its memory. The gathered cardiovascular data will qualify, cluster, and validate for each experiment with high quality data and increased level of “freedom to operate” of animals.

References: 

  1. Markert, M., Trautmann, T., Krause, F., Cioaga, M., Mouriot, S., Wetzel, M., & Guth, B. D. (2018). A new telemetry-based system for assessing cardiovascular function in group-housed large animals. Taking the 3Rs to a new level with the evaluation of remote measurement via cloud data transmission. Journal of Pharmacological and Toxicological Methods, 93, 90–97. https://doi.org/10.1016/j.vascn.2018.03.006  
  2. Home. (n.d.). Retrieved February 03, 2021, from https://www.tse-systems.com/