Public health interventions

Abstract

This project represents a formal research agreement between UA and on the other hand Erasmus Mundus. UA provides Erasmus Mundus research results mentioned in the title of the project under the conditions as stipulated in this contract.

Researchers

Principal investigator: Van geertruyden Jean-Pierre
Robert Colebunders

Period

09/12/2011-08/06/2012

The impact of retreatment with an artemisinin-based combination on malaria incidence and its potential selection of resistant strains

Abstract

The overall goal of the project is to identify if first line ACT can be safely and efficaciously used to retreat children with recurrent malaria occurring beyond 14 days after initial treatment and consequently preserve quinine for severe malaria treatment.

Researcher

Principal investigator: Van geertruyden Jean-Pierre

Period

29/09/2011-30/06/2013

The impact of artesunateamodiaquine retreatment and specific malaria humoral immunity on recrudescent malaria infections

Abstract

We will compare, in a non-inferiority, randomised, controlled trial, in Congolese children under 5 years of age, the efficacy of ASAQ to quinine as a rescue treatment for uncomplicated P. falciparum malaria. Additionally, given the key role of humoral immunity in protecting against malaria, we will assess antibody levels to merozoite antigens and VSAs in Congolese children under 5 with uncomplicated malaria and their association with anti-malarial treatment outcome.

Researcher

Principal investigator: Van geertruyden Jean-Pierre

Period

01/01/2011-31/12/2013

Monitoring and management of patients with HIV in Africa

Abstract

Within this project the management of patients with HIV in South Africa will be studied. Intervention studies will be performed to define the value of weight monitoring before and during antiretroviral treatment. Specifically studies will be looking at obese patients and patients who use alcohol.

Funding(s)

FWO

Researcher(s)

Principal investigator: Colebunders Robert

Period

01/10/2011-13/01/2014

Antibiotic resistant pathogenic bacteria present in the environment and human commensal flora: is there a link with disease?

Abstract

The main aim of this study is to provide a comprehensive picture of the level of clinical relevant antibiotic resistant bacteria (ARB) in the environment and commensal flora in Gauteng/South Africa. Besides, the genetic relatedness of these ARB will be studied to understand the mechanisms of antibiotic resistance dissemination in the community.

Funding(s)

FED. INST.

Researcher(s)

Principal investigator: Goossens Herman
Co-principal investigator: Colebunders Robert
Co-principal investigator: Malhotra Surbhi

Period

01/10/2010-09/05/2013

A multicentre phase III trial in Africa to evaluate the WHO second-line treatment strategies and a simplified maintenance regarding HIV infected patients

Abstract

This is a fundamental research project financed by the Research Foundation - Flanders (FWO). The project was subsidized after selection by the FWO-expert panel.

Funding(s)

FWO

Researcher(s)

Principal investigator: Colebunders Robert

Period

01/10/2009-30/09/2011

IRIS: Pathogenesis, clinical and public health aspects

Abstract

The pathogenesis, the clinical manifestations and the public health aspects of the Immune reconstitution inflammatoy syndrome (WS) will be studied. In Uganda and Ethiopia we will study how frequent a smear negative pulmonary TB patient with IRIS can become smear positive, and what the effect is of lRIS on the health service and the treatment adherence of the patient. Using blood samples obtained during a cohort study in Uganda, we will study whether VitD deficient; and the M. tuberculosis (TB) genotype/"antigen load" plays a role in the pathogenesis of TB-IRIS.

Funding(s)

FED. INST.

Researcher(s)

Principal investigator: Colebunders Robert

Period

01/10/2008-30/09/2012