The research group Veterinary Physiology and Biochemistry concentrates its academic scientific research within the Gameter Research Center, a platform where the female gamete, the embryo and the early embryonic development have a central position.
More specifically, (environmental) factors are studied that might have a (negative) influence on oocyte developmental capacity and embryo growth, including possible consequences during pregnancy, for the newborn and in later life. Most of this research is based on self-developed ''high throughput'' in vitro models, such as bovine, murine and zebrafish in vitro models for the study of follicular development, oocyte prematuration and maturation, fertilization and in vitro embryo culture.

Recent publications

'The effect of nutritionally-induced hyperlipidemia on in vitro bovine embryo quality depends on the major fatty acid type in the diet'

by Waleed Marei, accepted in Reproduction, Fertility and Development

'Exposure of bovine oocytes and embryos to elevated non-esterified fatty acid concentrations: integration of epigenetic and transcriptomic signatures in resultant blastocysts' 

by Karolien Desmetn accepted in BMC Genomics


Research Mission and Members
Research mission
Projects and Publications
PhD theses
Fertility Preservation
Maternal Metabolism and Fertility
Facilities and Collaborations
Equipment and Applications
Veterinary Services
News and Events

Research seminar

“Fatty acid metabolism in cumulus oocyte complexes: basic concepts and the consequences of an altered fatty acid micro-environment”

Dr. Svetlana Uzbekova 

INRA – French National Institute for Agriculture 

Physiologie de la Reproduction et des Comportements

Sponsered by the Flemish Government

The Gamete Research Centre research team would like to invite you to their seminar for young researchers on Tuesday 16th of May (9 a.m. – 1 p.m.) in the U-building, Campus Drie Eiken.

Invtation and Program


Prof. Dr. Peter Bols
(head research unit)
Campus Drie Eiken
U 0.09
Universiteitsplein 1
B-2610 Wilrijk
Tel. 0032 3 265 23 97
Tel. 0032 3 265 23 93

1    More activities and calendar

Key publications

Bovine in vitro reproduction models can contribute to the development of (female) fertility preservation strategies

Langbeen An, De Porte Hannelore F.M., Bartholomeus Esther, Leroy Jo, Bols Peter, Theriogenology 84:4(2015), p. 477-489

Morphologic characterization of isolated bovine early preantral follicles during short-term individual in vitro culture

Jorssen Ellen, Langbeen An, Marei Waleed, Fransen Erik, De Porte H.F.M., Leroy Jo, Bols Peter, Theriogenology 84(2015),p. 301-311

Nutrition and maternal metabolic health in relation to oocyte and embryo quality : critical views on what we learned from the dairy cow model

Leroy Jo, Valckx Sara, Jordaens Lies, De Bie Jessie, Desmet Karolien, Van Hoeck Veerle, Britt Jack H., Marei Waleed, Bols Peter, Reproduction, fertility and development 1031-3613-(2015),p. 1-28

Elevated non-esterified fatty acid concentrations during in vitro murine follicle growth alter follicular physiology and reduce oocyte developmental competence 

Valckx SD, Van Hoeck V, Arias-Alvarez M, Maillo V, Lopez-Cardona AP, Gutierrez-Adan A, Berth M, Cortvrindt R, Bols PE, Leroy JL, Fertility and Sterility, Volume 102, Issue 6, December 2014, Pages 1769–1776

PFOS affects posterior swim bladder chamber inflation and swimming performance of zebrafish larvae

Hagenaars A, Stinckens E, Vergauwen L, Bervoets L, Knapen D, Aquat Toxicol. 2014 Dec;157:225-35

The potential of AOP networks for reproductive and developmental toxicity assay development

Knapen D, Vergauwen L, Villeneuve DL, Ankley GT, Reprod Toxicol. 2015 Aug 15;56:52-5

A high throughput passive dosing format for the Fish Embryo Acute Toxicity test

Vergauwen L, Schmidt SN, Stinckens E, Maho W, Blust R, Mayer P, Covaci A, Knapen D, Chemosphere. 2015 Nov;139:9-17